Y.L.B. K.
- Country
- The Netherlands
- Department
- Radiotherapy
Research Overview
Data & Insights
Has run more than one trial at 0 of 14 partner sites.
Specializations
HER2‑Targeted Oncology
Investigation of HER2‑positive esophageal adenocarcinoma using monoclonal antibodies to augment standard treatment.
- HER2‑positive esophageal adenocarcinoma
- HER2‑targeted monoclonal antibodies
- Trastuzumab
- Pertuzumab
Focuses on integrating targeted agents to improve overall survival outcomes.
Esophageal and Gastroesophageal Junction Cancer
Clinical emphasis on malignancies of the esophagus and the gastro‑esophageal junction, encompassing both adenocarcinoma and squamous histologies.
- Oesophageal cancer
- Oesophagogastric junction cancer
- Adenocarcinoma histology
- Disease staging
Supports multidisciplinary management and precise patient selection.
Neoadjuvant Chemoradiation Strategies
Development of neoadjuvant chemoradiation protocols to enhance tumor downstaging before resection.
- Neoadjuvant chemoradiation
- Preoperative chemoradiotherapy
- Multimodal regimens
- Surgical outcomes
Aims to increase pathological response rates and resectability.
Total Neoadjuvant Therapy (TNT) Approaches
Exploration of intensive Total Neoadjuvant Therapy sequences to prolong disease control.
- Total Neoadjuvant Therapy
- TNT FLOT‑CROSS
- TNT CROSS‑FLOT
- Progression‑free survival
Targets extended progression‑free intervals through combined regimens.
Radiotherapy Innovation in Upper GI Cancers
Application of advanced proton therapy techniques to optimize dose delivery for esophageal malignancies.
- Proton therapy
- Dose escalation
- Organ‑sparing techniques
- Radiobiology
Utilizes the capabilities of the Holland Protonen Therapie Centrum for precision treatment.
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