Xavier P. S.
- Country
- Spain
- Department
- #4201:Servicio de Cardiología
Research Overview
- J3L-MC-EZEB: A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of LY3819469 in Adults with Elevated Lipoprotein(a)
- Effect of Muvalaplin on Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) and Atherosclerotic Cardiovascular Disease: A Phase 3 Randomized Trial
- Evaluation of Inclisiran's Efficacy in Reducing Major Adverse Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
Data & Insights
Has run more than one trial at 419 of 1021 partner sites.
Specializations
Cardiovascular medicine and lipid disorders
Clinical research activity centers on atherosclerotic cardiovascular disease, coronary artery disease, myocardial infarction, atrial fibrillation, and heart failure, with additional interest in hypercholesterolemia, severe hypertriglyceridemia, and elevated lipoprotein(a).
- ASCVD
- Acute coronary syndromes
- Heart failure
- Lipoprotein(a) elevation
- Familial hypercholesterolemia
Work in this area also includes cardiomyopathy, stroke prevention, and antithrombotic therapy in high-risk cardiovascular settings.
Renal diseases and kidney transplantation
Research involvement includes chronic kidney disease, IgA nephropathy, lupus nephritis, primary membranous nephropathy, and end-stage renal disease, together with post-transplant complications and graft protection.
- Kidney transplantation
- Antibody-mediated rejection
- Renal allograft rejection
- Proteinuric kidney disease
- Dialysis-associated renal disease
Additional interest extends to Fabry disease, renal transplant recipients, and metabolic risk in kidney disease.
Amyloidosis and inherited cardiometabolic disease
The investigator is involved in studies of transthyretin amyloidosis, cardiac amyloidosis, AL amyloidosis, and related amyloid cardiomyopathy presentations, alongside inherited lipid and metabolic conditions.
- ATTR cardiomyopathy
- Hereditary transthyretin amyloidosis
- AL amyloidosis
- Familial lipid disorders
- Genetic cardiomyopathy
This area also includes cardiac imaging for amyloid disease and genotype-driven treatment strategies.
Respiratory and pulmonary fibrosis research
Clinical trial activity covers idiopathic pulmonary fibrosis, progressive pulmonary fibrosis, interstitial lung disease, pulmonary sarcoidosis, and chronic obstructive pulmonary disease, with attention to inflammatory and fibrotic lung disorders.
- Interstitial lung disease
- Idiopathic pulmonary fibrosis
- COPD
- Pulmonary sarcoidosis
- Bronchiectasis
Related interests include severe pneumonia, asthma with type 2 inflammation, and respiratory infections.
Autoimmune, neuromuscular, and metabolic conditions
Research spans systemic autoimmune disease, dermatologic inflammation, neuromuscular disorders, type 2 diabetes, and severe hypertriglyceridemia, reflecting involvement across chronic multisystem disease domains.
- Dermatomyositis
- Myasthenia gravis
- Psoriasis
- Atopic dermatitis
- Diabetic retinopathy
Additional therapeutic interests include vitiligo, multiple sclerosis, and metabolic inflammation.
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