Xavier D.
- Country
- France
- Department
- Service d’oncologie
Research Overview
- PREDOSTAR - PREventing second cancers with DOSTARlimab - A multicenter, open-label, randomized phase II study aiming to assess the clinical impact of dostarlimab on occurrence of second primary cancer in patients with cured primary cancer
- ETIC-LM_Multicentric single arm phase II study evaluating the Efficacy of association of Tucatinib, capecitabine and Intra-CSF trastuzumab in HER2 amplified breast cancer patients with Leptomeningeal Metastases.
- Phase II Study of Sequential Encorafenib and Binimetinib Followed by Nivolumab and Ipilimumab Versus Immediate Nivolumab and Ipilimumab in BRAF V600 Mutant Melanoma
Data & Insights
Has run more than one trial at 125 of 304 partner sites.
Specializations
Breast Cancer Research
The investigator specializes in treating various forms of breast cancer, with particular focus on hormone receptor-positive (HR+) and HER2-negative variants. Their research encompasses both localized and metastatic disease states.
- Metastatic breast cancer management
- Hormone receptor-positive disease treatment
- Leptomeningeal metastases therapy
The investigator explores innovative treatment combinations including targeted therapies and immunotherapy approaches for breast cancer patients.
Brain Cancer Studies
Focuses on advanced treatment approaches for glioblastoma and diffuse intrinsic pontine glioma (DIPG). Their work includes investigating novel therapeutic strategies for both newly diagnosed and recurrent cases.
- Glioblastoma treatment optimization
- Pediatric brain tumors
- Radiation therapy combinations
The investigator evaluates various treatment intensification strategies and combination therapies for brain tumors.
Advanced Solid Tumors
Conducts research on advanced solid tumors with specific genetic mutations, including KRAS G12C mutations and FGFR alterations. Their work extends to various cancer types including melanoma and sarcoma.
- Targeted therapy development
- Immunotherapy applications
- Mutation-specific treatments
The investigator explores personalized treatment approaches based on specific genetic markers and tumor characteristics.
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