Winfried Henning A.
- Country
- Germany
- Department
- II. Medizinische Klinik
Research Overview
- A Phase I Study of TK-6302 in Patients with Advanced PRAME-Positive Solid Tumors Harboring the HLA-A*02:01 Allele
- Phase 1/2a Study of REGN10597 Alone or with Cemiplimab in Patients with Advanced Solid Tumours, Melanoma, or Clear-Cell Renal Cell Carcinoma
- Phase III Randomized Trial of De-escalated MATRix Induction Therapy in Newly Diagnosed Primary CNS Lymphoma: Methotrexate, Cytarabine, Thiotepa, and Rituximab
Data & Insights
Has run more than one trial at 8 of 67 partner sites.
Specializations
Haematology and Blood Disorders
The investigator is involved in clinical research across acute leukaemias, lymphoid malignancies, and plasma cell disorders, with additional interest in inherited and acquired bleeding conditions.
- Acute myeloid leukaemia
- Acute lymphoblastic leukaemia
- Multiple myeloma
- Haemophilia
- Myelodysplastic syndrome
Research activity also includes cell therapy, haematopoietic stem cell transplantation, and treatment approaches for high-risk or relapsed blood cancers.
Solid Tumours and Oncology
Clinical work spans a wide range of solid tumours, with particular focus on breast cancer, prostate cancer, lung cancer, and gastrointestinal malignancies.
- Breast cancer
- Prostate cancer
- Non-small cell lung cancer
- Gastric and gastroesophageal junction cancer
- Ovarian cancer
There is also involvement in research on melanoma, head and neck cancer, urothelial carcinoma, and other advanced or metastatic solid malignancies.
Cardiovascular Medicine
The investigator contributes to studies in atherosclerotic cardiovascular disease, atrial fibrillation, and myocardial infarction, with attention to prevention of major cardiovascular complications.
- Atrial fibrillation
- Acute myocardial infarction
- Heart failure
- Stroke prevention
- Atherosclerotic cardiovascular disease
Additional interests include cardiometabolic risk, hypertension, and cardiovascular outcomes in high-risk patient groups.
Transplantation and Immune-Mediated Disease
Research involvement extends to solid organ transplantation, graft-versus-host disease, and antibody-mediated rejection, reflecting a strong interest in immune regulation after transplantation.
- Kidney transplantation
- Liver transplantation
- Chronic graft-versus-host disease
- Antibody-mediated rejection
- Transplant rejection prophylaxis
Related work also covers autoimmune disease, inflammatory disorders, and immune-mediated complications affecting kidney and liver function.
Renal, Hepatic, and Rare Diseases
The investigator is active in trials for chronic kidney disease, proteinuric glomerular disease, and selected rare metabolic and genetic disorders.
- Chronic kidney disease
- Focal segmental glomerulosclerosis
- Primary sclerosing cholangitis
- Amyloidosis
- Generalised lipodystrophy
Research also includes cholestatic liver disease, amyloid disorders, and other uncommon conditions requiring specialised therapeutic development.
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