W.K. D. J.
- Country
- The Netherlands
- Department
- Pulmonary Medicine
Research Overview
- Therapeutic Drug Monitoring-Guided Versus Standard Dosing of Alectinib in ALK-Positive Non-Small Cell Lung Cancer Patients
- Evaluation of Extended Dosing Interval of Osimertinib in EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Increasing the dosing interval of osimertinib in patients with EGFR mutated locally advanced or meta-static non-small cell lung cancer - OSI-SAVE
Data & Insights
Has run more than one trial at 7 of 20 partner sites.
Specializations
Respiratory and Pulmonary Medicine
The investigator concentrates on chronic lung diseases, emphasizing interstitial lung pathology, bronchiectasis, and cystic fibrosis‑related pulmonary complications.
- Interstitial lung disease
- Bronchiectasis management
- Cystic fibrosis respiratory care
- Acute respiratory infections in critical care
These efforts aim to improve functional outcomes and quality of life for patients with persistent pulmonary impairment.
Cardiovascular and Metabolic Disorders
Focused on atherosclerotic cardiovascular disease and related metabolic conditions, the investigator explores therapeutic strategies for heart failure, hypertension, and dyslipidemia.
- Heart failure with reduced ejection fraction
- Hypertensive disease management
- Hypertriglyceridemia treatment
- Peripheral arterial disease interventions
The work supports reducing cardiovascular risk and preventing disease progression.
Oncology and Hematologic Malignancies
The investigator’s oncology portfolio spans solid tumors and blood‑cancer subtypes, with a particular interest in lung, renal, and gastrointestinal malignancies.
- Non‑small cell lung cancer
- Renal cell carcinoma
- Colorectal cancer with hepatic metastasis
- Acute myeloid leukemia
These studies target novel therapeutic avenues to enhance survival across diverse cancer phenotypes.
Rare and Genetic Disorders
Specialized investigations address hereditary and rare systemic diseases, including amyloid cardiomyopathy, osteogenesis imperfecta, and metabolic enzyme deficiencies.
- Transthyretin amyloid cardiomyopathy
- Osteogenesis imperfecta type III/IV
- Methylmalonic acidemia
- Primary immunodeficiency syndromes
These initiatives aim to translate genetic insights into targeted clinical interventions.
Immunology and Autoimmune Diseases
In the field of immune‑mediated disorders, the investigator explores therapeutic modulation of autoimmune pathways in conditions such as systemic lupus erythematosus, inflammatory bowel disease, and vasculitis.
- Systemic lupus erythematosus
- Inflammatory bowel disease (Crohn’s and ulcerative colitis)
- ANCA‑associated vasculitis
- Myasthenia gravis subtypes
Research focuses on advancing disease‑specific immunotherapies to achieve durable remission.
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