Vladimir Z.
- Country
- Bulgaria
- Department
- N/A
Research Overview
- Effect of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein(a): A Randomized, Placebo-Controlled Study
- Evaluation of Obicetrapib on Major Adverse Cardiovascular Events in Atherosclerotic Cardiovascular Disease Patients on Maximal Lipid-Modifying Therapy
- Phase 3 Randomized Study Comparing Asundexian and Apixaban for Stroke Prevention in Atrial Fibrillation Patients at Risk
Data & Insights
Has run more than one trial at 652 of 1367 partner sites.
Specializations
Cardiovascular Disease and Lipid-Lowering Therapy
Clinical research activity includes atherosclerotic cardiovascular disease, high cardiovascular risk, hypercholesterolemia, and prevention of major cardiovascular events in patients requiring intensified lipid management.
- ASCVD and primary prevention
- LDL-C reduction
- Lipoprotein(a) and residual risk
- Cardiovascular event prevention
Research interests also extend to therapies targeting persistent cardiovascular risk despite standard treatment, with emphasis on long-term vascular protection.
Heart Failure and Blood Pressure Disorders
Investigator involvement covers heart failure across preserved, mildly reduced, and reduced ejection fraction phenotypes, as well as hypertension and resistant hypertension.
- HFpEF and HFmrEF
- HFrEF
- Uncontrolled hypertension
- Cardiorenal and metabolic overlap
The therapeutic focus includes strategies aimed at reducing heart failure events and improving management of complex blood pressure-related cardiovascular disease.
Thromboembolic Risk and Atrial Fibrillation
Clinical trial participation includes prevention of stroke and systemic embolism in atrial fibrillation, with attention to patients at elevated cardiovascular risk.
- Cardioembolic event prevention
- Bleeding-risk balanced anticoagulation
- Stroke prevention
- Arrhythmia-related vascular protection
This area reflects interest in newer options for reducing thrombotic complications while supporting safer long-term cardiovascular care.
Inflammatory and Autoimmune Disease
Research activity includes rheumatoid arthritis, psoriatic arthritis, and chronic spontaneous urticaria, with a therapeutic emphasis on immune-mediated disease control.
- Rheumatoid arthritis
- Psoriatic arthritis
- Chronic spontaneous urticaria
- Inflammation-driven symptom burden
The portfolio includes interest in biologic and targeted therapies for persistent inflammatory conditions affecting joints and skin.
Metabolic Disease and Psychiatric Symptoms
Additional research spans type 2 diabetes, hypertriglyceridemia, and major depressive disorder with insomnia symptoms, indicating involvement in both metabolic and neuropsychiatric treatment areas.
- Severe hypertriglyceridemia
- Metabolic cardiovascular risk
- Sleep-related depressive symptoms
- Cardiometabolic disease
These interests align with therapies addressing lipid disorders, glycemic risk, and depressive symptoms with sleep disturbance.
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