Violaine R.
- Country
- France
- Department
- Gastro enterology and hepatology
Research Overview
- Phase 3 Randomized Double-Blind Study of INCA33890 Plus First-Line Chemotherapy and Bevacizumab in Metastatic Microsatellite Stable Colorectal Cancer
- Postoperative Hepatic Arterial Oxaliplatin Infusion Combined with Systemic Chemotherapy for High‑Risk Resected Colorectal Liver Metastases: A Randomized Phase II Trial
- Evaluation of Zanidatamab in Adult Patients with HER2-Overexpressing or Mutant Solid Tumors, Including Endometrial, Colorectal, Head & Neck, Sarcoma, and NSCLC
Data & Insights
Has run more than one trial at 36 of 154 partner sites.
Specializations
Breast Oncology
Clinical research activity includes HER2-positive breast cancer, hormone receptor-positive breast cancer, triple-negative breast cancer, and early breast cancer with a focus on treatment intensification, biomarker-guided selection, and treatment de-escalation.
- HER2-positive metastatic breast cancer
- HR+/HER2- advanced breast cancer
- Triple-negative breast cancer
- Early-stage breast cancer recurrence prevention
Interest extends to antibody-based therapies, endocrine treatment strategies, and circulating tumor DNA-informed therapeutic decisions.
Gastrointestinal and Hepatobiliary Oncology
Research involvement covers colorectal cancer, gastric and gastroesophageal junction adenocarcinoma, esophageal cancer, pancreatic cancer, biliary tract cancer, and hepatocellular carcinoma.
- Metastatic colorectal cancer
- Advanced gastric and GEJ adenocarcinoma
- Pancreatic ductal adenocarcinoma
- Advanced hepatocellular carcinoma
Therapeutic themes include targeted therapy, immunotherapy, and management of biomarker-defined gastrointestinal malignancies.
Hematologic Malignancies
Clinical trial activity is centered on acute leukemia, lymphoma, multiple myeloma, myelodysplastic syndromes, and myeloproliferative neoplasms, including both newly diagnosed and relapsed or refractory disease.
- Acute lymphoblastic leukemia
- Diffuse large B-cell lymphoma
- Multiple myeloma
- Myelodysplastic syndromes
Key therapeutic interests include cellular therapy, bispecific and monoclonal antibody approaches, and transplant-related treatment strategies.
Thoracic and Rare Solid Tumors
Investigational work includes non-small cell lung cancer, head and neck squamous cell carcinoma, sarcoma, renal cell carcinoma, melanoma, and selected rare solid tumors.
- Advanced non-small cell lung cancer
- Head and neck cancer
- Soft tissue sarcoma
- Renal cell carcinoma
Therapeutic focus includes immune checkpoint inhibition, molecularly targeted treatment, and approaches for advanced metastatic disease.
Cardiovascular, Autoimmune, and Medical Supportive Care
Research also spans acute myocardial infarction, stroke, heart failure, atrial fibrillation, pulmonary hypertension, and autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus.
- Acute coronary and cerebrovascular disease
- Heart failure and atrial fibrillation
- Autoimmune inflammatory disease
- Infectious and intensive care medicine
Additional interests include thrombosis prevention, infection management, and supportive care in hospitalized patients.
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