Velko M.
- Country
- Bulgaria
- Department
- Department of medical oncology
Research Overview
- A Comparative Study of ABP 234 and Pembrolizumab in Patients with Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
- Phase III Randomized Open‑Label Study of Atezolizumab + Lenvatinib or Sorafenib vs Lenvatinib/Sorafenib Alone in Previously Treated Unresectable HCC
- Phase 3 Randomized Study of Telisotuzumab Vedotin vs. Docetaxel in c-Met Overexpressing EGFR Wildtype Non-Squamous NSCLC
Data & Insights
Has run more than one trial at 289 of 564 partner sites.
Specializations
Thoracic Oncology
Clinical research in non-small cell lung cancer spans EGFR-mutated, HER2-altered, c-Met overexpressing, and advanced metastatic disease, with interest in both first-line and later-line treatment settings.
- Non-small cell lung cancer
- Small cell lung cancer
- HER2-driven lung cancer
- EGFR-mutated lung cancer
- c-Met–expressing lung cancer
Work in this area also includes neoadjuvant, adjuvant, and metastatic treatment strategies for lung malignancies.
Genitourinary and Prostate Cancer
The investigator is involved in studies of urothelial cancer, advanced prostate cancer, metastatic castration-resistant prostate cancer, and metastatic hormone-sensitive prostate cancer, with attention to biomarker-defined disease such as PTEN deficiency.
- Urothelial cancer
- Prostate cancer
- PTEN-deficient disease
- Hormone-sensitive metastatic disease
- Castration-resistant prostate cancer
Additional activity includes treatment evaluation in locally advanced and metastatic urinary tract malignancies.
Hematologic Malignancies and Immune Thrombocytopenia
Research interests extend to chronic lymphocytic leukemia, multiple myeloma, non-Hodgkin lymphoma, myelodysplastic syndrome, and immune thrombocytopenia, reflecting activity across malignant and immune-mediated blood disorders.
- Chronic lymphocytic leukemia
- Multiple myeloma
- Non-Hodgkin lymphoma
- Myelodysplastic syndrome
- Immune thrombocytopenia
The therapeutic focus also includes hypogammaglobulinemia and infection-related complications in hematologic disease.
Cardiometabolic and Renal Medicine
Clinical trial involvement covers acute myocardial infarction, acute coronary syndrome, heart failure, chronic kidney disease, type 2 diabetes, obesity, and severe hypertriglyceridemia, with strong interest in cardiometabolic risk reduction.
- Acute myocardial infarction
- Heart failure
- Chronic kidney disease
- Type 2 diabetes
- Obesity
Research activity also includes cardiovascular event prevention and therapies targeting metabolic and renal complications.
Hepatic, Autoimmune, and Gastrointestinal Disorders
The investigator is active in studies of chronic hepatitis B, chronic hepatitis delta, non-alcoholic steatohepatitis, systemic lupus erythematosus, axial spondyloarthritis, and ulcerative colitis, indicating a broad therapeutic scope in inflammatory and immune-mediated disease.
- Chronic hepatitis B
- Chronic hepatitis delta
- Non-alcoholic steatohepatitis
- Systemic lupus erythematosus
- Ulcerative colitis
Work in this domain also includes immune modulation and liver-directed therapeutic development.
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