Valentina G.
- Country
- Spain
- Department
- Oncologia
Research Overview
Data & Insights
Has run more than one trial at 0 of 2 partner sites.
Specializations
Hormone Receptor‑Positive Breast Cancer
Investigations target advanced Estrogen Receptor Positive / HER2‑negative disease, focusing on endocrine resistance and novel combination regimens.
- Endocrine therapy resistance
- CDK4/6 inhibitor combinations
- PIK3CA‑mutated disease
- Neoadjuvant endocrine strategies
- Biomarker‑guided treatment sequencing
Research integrates molecular profiling to refine therapeutic sequencing for Estrogen Receptor Positive tumors.
HER2‑Targeted Breast Cancer
Efforts concentrate on HER2‑positive and HER2‑low metastatic breast cancer, evaluating antibody‑drug conjugates and dual HER2 blockade.
- HER2‑positive metastatic disease
- HER2‑low expression
- Antibody‑drug conjugates
- Dual HER2 blockade strategies
- Brain metastasis management
Trials assess novel agents in HER2 Negative and HER2‑low contexts to broaden therapeutic options.
Hematologic Malignancies
Focused on acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms, with emphasis on targeted molecular interventions.
- Acute Myeloid Leukemia therapy optimization
- IDH1/2 mutation targeting
- Myelodysplastic syndrome risk stratification
- Allogeneic transplantation approaches
- Targeted treatment for myelofibrosis
Molecular classification guides precision approaches in Acute Myeloid Leukemia cohorts.
KRAS‑Driven Solid Tumors
Advanced colorectal, non‑small cell lung, and pancreatic cancers with KRAS mutations are studied for mutation‑specific therapeutic strategies.
- KRAS G12C inhibition
- Combination with EGFR blockade
- Biomarker‑selected enrollment
- Resistance mechanism elucidation
- Early‑line KRAS‑directed therapy
Integration of KRAS G12C status into trial design supports mutation‑specific drug development.
Cardio‑Oncology and Organ Dysfunction
Addressing cardiovascular complications arising in cancer patients, including heart failure, acute hepatic decompensation, and respiratory distress.
- Cancer‑associated Heart Failure
- Acute coronary syndrome in oncology
- Acute‑on‑Chronic Liver Failure in hepatic malignancies
- Pulmonary embolism risk management
- Cardio‑protective strategies during systemic therapy
Collaborative efforts with cardiology aim to mitigate Heart Failure impact on cancer therapy outcomes.
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