Valentin R.
- Country
- France
- Department
- Service d’hépato-gastro-entérologie et assistance nutritive
Research Overview
- TERTIO : Evaluation of the interest to combine a CD4 Th1-inducer cancer vaccine derived from telomerase and atezolizumab plus bevacizumab in unresectable hepatocellular carcinoma: a proof of concept randomized phase II study
- Evaluation of Bezafibrate 400 mg and 200 mg as Adjunctive Therapy in Primary Biliary Cholangitis with Suboptimal Ursodeoxycholic Acid Response: A Randomized, Double-Blind, Placebo-Controlled Trial
- Evaluation of Prolonged Prednisolone and N-Acetylcysteine in Severe Alcoholic Hepatitis: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 18 of 42 partner sites.
Specializations
Gastroenterology and Hepatology
Clinical research activity includes colorectal cancer, gastric cancer, gastroesophageal junction adenocarcinoma, pancreatic adenocarcinoma, cholangiocarcinoma, hepatocellular carcinoma, esophageal cancer, and biliary tract cancer, with additional interest in inflammatory and cholestatic liver disease.
- Colorectal cancer and rectal cancer
- Gastric, esophageal, and gastroesophageal junction cancers
- Hepatocellular carcinoma and biliary tract cancer
- Crohn’s disease and primary sclerosing cholangitis
The therapeutic focus also extends to digestive neuroendocrine tumors, gastrointestinal stromal tumor, and alcoholic hepatitis, reflecting broad involvement in digestive oncology and liver disease.
Hematology and Blood Cancers
Research interests cover acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia, myelodysplastic syndromes, multiple myeloma, lymphoma, Waldenström macroglobulinemia, and myelofibrosis, alongside related precursor and relapsed disease states.
- Acute lymphoblastic leukemia and acute myeloid leukemia
- Multiple myeloma and plasma cell disorders
- Lymphomas including diffuse large B-cell lymphoma and follicular lymphoma
- Myelodysplastic syndromes and myelofibrosis
Additional activity includes amyloidosis, systemic mastocytosis, mastocytosis, and hemophilia, indicating a strong therapeutic presence across malignant and non-malignant hematologic conditions.
Solid Tumors and Precision Oncology
Clinical trial involvement spans breast cancer, non-small cell lung cancer, renal cell carcinoma, ovarian cancer, prostate cancer, melanoma, head and neck cancer, bladder cancer, and sarcomas, including rare and biomarker-defined malignancies.
- Breast cancer, including HER2-positive and triple-negative disease
- Non-small cell lung cancer and ROS1-positive lung cancer
- Renal cell carcinoma, urothelial carcinoma, and prostate cancer
- Sarcomas, melanoma, and head and neck squamous cell carcinoma
Interest also includes FGFR-altered tumors, HER2-mutated solid tumors, MSI-H and dMMR cancers, and other biomarker-selected advanced cancers.
Cardiovascular and Thrombotic Disease
Research activity includes acute myocardial infarction, acute coronary syndrome, stroke, atrial fibrillation, heart failure, atherosclerotic cardiovascular disease, hypertension, and pulmonary arterial hypertension, with attention to both prevention and acute management.
- Acute myocardial infarction and acute coronary syndrome
- Stroke and transient ischemic attack
- Atrial fibrillation and cardioembolic risk
- Heart failure, hypertension, and atherothrombotic disease
Additional therapeutic interest extends to valvular heart disease, cardiac arrest, cardiomyopathy, and venous thromboembolism.
Autoimmune, Inflammatory, and Transplant Conditions
Clinical research includes rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, juvenile idiopathic arthritis, vasculitis, Crohn’s disease, systemic sclerosis, and giant cell arteritis, together with transplant-related immune disorders.
- Rheumatoid arthritis and juvenile idiopathic arthritis
- Systemic lupus erythematosus and lupus nephritis
- Vasculitis and giant cell arteritis
- Kidney transplantation and graft-versus-host disease
Therapeutic interests also cover immune thrombocytopenia, primary biliary cholangitis, systemic mastocytosis, and pulmonary hypertension linked to inflammatory disease.
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