Valentin M.
- Country
- Romania
- Department
- Psychiatry
Research Overview
- A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NBI-1117570 in Hospitalized Adults with Schizophrenia
- Adjunctive Aticaprant and Antidepressant Therapy for Relapse Prevention in Major Depressive Disorder with Moderate-to-Severe Anhedonia: A Randomized, Double-Blind Study
- Efficacy and Safety of Seltorexant as Adjunctive Therapy in Major Depressive Disorder with Insomnia Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study
Data & Insights
Has run more than one trial at 66 of 196 partner sites.
Specializations
Schizophrenia and Psychotic Disorders
Clinical research activity includes schizophrenia, acute psychosis, and treatment-resistant psychotic symptoms, with attention to both adult and adolescent populations. The investigator is also involved in studies addressing schizophrenia-associated cognitive impairment and persistent behavioral symptoms.
- Acute schizophrenia
- Psychosis in adolescents and adults
- Negative symptoms and cognitive impairment
- Adjunctive treatment for persistent psychotic symptoms
Additional interest extends to psychosis linked with Alzheimer’s disease, including hallucinations, delusions, and broader neuropsychiatric symptoms.
Bipolar Disorder and Mood Instability
The investigator is engaged in trials focused on bipolar I disorder, especially acute mania and mania with mixed features. This area includes work on symptom control and maintenance of therapeutic benefit in mood episodes.
- Bipolar I disorder
- Manic episodes
- Mania with mixed features
- Adjunctive mood stabilization
Research activity also includes depressive symptom relapse prevention in major depressive disorder, with a focus on anhedonia and persistent depressive burden.
Alzheimer’s Disease Neuropsychiatry
Another major area of interest is the treatment of Alzheimer’s disease-related behavioral and psychiatric symptoms, including agitation, psychosis, and hallucinations or delusions. The investigator’s portfolio also includes studies targeting cognitive and global functional impairment in mild to moderate disease.
- Agitation associated with Alzheimer’s dementia
- Psychosis associated with Alzheimer’s disease
- Hallucinations and delusions
- Cognitive and global functioning impairment
This therapeutic focus reflects involvement in neuropsychiatric care for dementia-related symptom management.
Pediatric Neurology and Developmental Disorders
The investigator is active in pediatric neurological conditions, including multiple sclerosis, epilepsy, migraine, and Tourette’s disorder. Research spans childhood and adolescent populations, with attention to chronic neurological disease management and symptom relief.
- Pediatric multiple sclerosis
- Childhood absence epilepsy and juvenile absence epilepsy
- Pediatric migraine
- Tourette’s disorder
In multiple sclerosis, the work includes relapsing-remitting disease and pediatric treatment options.
Neurological and Psychiatric Therapeutics
Broader clinical interests include major depressive disorder, suicidal ideation in adolescents, and symptom-focused treatment in complex neuropsychiatric presentations. The investigator is also involved in studies of Lennox-Gastaut syndrome, adding to a diverse neurological portfolio.
- Major depressive disorder
- Adolescent depression with suicidal ideation
- Lennox-Gastaut syndrome
- Behavioral and psychiatric symptom management
These areas reflect a clinical emphasis on neurological disease states with overlapping psychiatric and behavioral manifestations.
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