Cristinel Ș.
- Country
- Romania
- Department
- Sectia 5 Acuti
Research Overview
- A Phase 2a Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of NBI-1117570 in Hospitalized Adults with Schizophrenia
- Evaluation of Valbenazine as Adjunctive Therapy in Schizophrenia Patients with Inadequate Antipsychotic Response: A Phase 3 Randomized, Double-Blind, Placebo-Controlled Trial
- Adjunctive Aticaprant and Antidepressant Therapy for Relapse Prevention in Major Depressive Disorder with Moderate-to-Severe Anhedonia: A Randomized, Double-Blind Study
Data & Insights
Has run more than one trial at 72 of 195 partner sites.
Specializations
Schizophrenia and Acute Psychosis
Schizophrenia, acute psychotic states, and persistent behavioral symptoms are central to the investigator’s clinical trial activity, with attention to symptom control in both adult and adolescent populations.
- Acute schizophrenia
- Acutely psychotic patients with schizophrenia
- Behavioral and psychological symptoms of schizophrenia
- Schizophrenia in adolescents
Work in this area also includes inpatient care settings and studies focused on ongoing symptom burden in difficult-to-treat schizophrenia.
Bipolar I Disorder and Mania
Bipolar I disorder and manic episodes, including presentations with mixed features, form another major therapeutic focus, particularly for acute stabilization and longer-term symptom management.
- BP-I mania
- Mania with mixed features
- Acute mania
- Manic episodes in bipolar-I disorder
This area reflects active involvement in treatments aimed at reducing manic severity across monotherapy and adjunctive treatment settings.
Alzheimer’s Disease Neuropsychiatry
Alzheimer’s disease is represented through trials addressing neuropsychiatric complications such as agitation, hallucinations, and delusions, alongside cognitive and global functional impairment.
- Agitation associated with Alzheimer’s disease
- Hallucinations and delusions associated with Alzheimer’s disease psychosis
- Mild to moderate Alzheimer’s disease
- Cognitive impairment and global functioning
The clinical profile in this domain centers on psychiatric symptoms linked to dementia and their impact on daily function.
Major Depressive Disorder and Anhedonia
Major depressive disorder with moderate-to-severe anhedonia and insomnia symptoms is another key area, with emphasis on symptom relief and relapse prevention in adults receiving antidepressant therapy.
- Major depressive disorder with moderate-to-severe anhedonia
- Major depressive disorder with insomnia symptoms
- Relapse prevention in depression
- Adjunctive antidepressant treatment
This research area also includes treatment strategies for residual depressive symptoms that persist despite standard antidepressant care.
Psychiatric Care in Specialized Clinical Settings
The investigator’s activity is linked to a psychiatric research site in Iasi, Romania, with a clinical emphasis on complex neuropsychiatric disorders managed in specialized hospital-based care.
- Institutul De Psihiatrie Socola Lasi
- Inpatient adult schizophrenia
- Psychiatric symptom management
- Neuropsychiatric disorders in specialized care
These studies place the investigator within therapeutic domains that bridge psychosis, mood disorders, and dementia-related behavioral symptoms.
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