Toshko L.
- Country
- Bulgaria
- Department
- III Department of Clinical Hematology
Research Overview
- Phase Ib Study of TU7710: Safety, Pharmacokinetics, and Pharmacodynamics in Patients with Hemophilia A or B
- A Global, Open-label, Adaptive Design Study to Investigate the Efficacy and Safety of SerpinPC in Subjects With Severe Hemophilia A or Moderately Severe to Severe Hemophilia B (PRESent-2)
- An 18-month low-interventional prospective, multicentre study to assess joint outcomes in patients with haemophilia A or B on prophylaxis with efmoroctocog alfa or eftrenonacog alfa
Data & Insights
Has run more than one trial at 6 of 64 partner sites.
Specializations
Hematologic malignancies
Clinical research activity includes acute myeloid leukemia, chronic myeloid leukemia, chronic lymphocytic leukemia, myelodysplastic syndrome, myelofibrosis, diffuse large B-cell lymphoma, follicular lymphoma, marginal zone lymphoma, and multiple myeloma, with additional involvement in Philadelphia chromosome-positive acute lymphoblastic leukemia and other advanced lymphoproliferative disorders.
- Acute myeloid leukemia
- Myelodysplastic syndrome
- Myelofibrosis
- Diffuse large B-cell lymphoma
- Chronic lymphocytic leukemia
The therapeutic scope also extends to hematologic supportive care, including chemotherapy-induced thrombocytopenia and infection-related complications in blood cancers.
Thrombosis and hemostatic disorders
Investigational work covers hemophilia A, hemophilia B, immune thrombocytopenia, thromboembolic disease, venous thromboembolism, and cancer-associated thrombosis, together with prevention strategies in high-risk settings such as catheter placement and orthopedic surgery.
- Hemophilia A
- Hemophilia B
- Immune thrombocytopenia
- Venous thromboembolism
- Cancer-associated thrombosis
Interest also includes anticoagulation, bleeding risk, and peri-procedural thromboprophylaxis.
Cardiovascular and metabolic medicine
Clinical trial involvement spans heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, acute myocardial infarction, hypertension, hypercholesterolemia, hypertriglyceridemia, and elevated lipoprotein(a), with emphasis on risk reduction in patients with established or high-risk cardiovascular disease.
- Heart failure
- Atrial fibrillation
- Atherosclerotic cardiovascular disease
- Hypertriglyceridemia
- Acute myocardial infarction
Metabolic interests also include obesity and cardiometabolic risk in patients with systemic inflammatory disease.
Immune-mediated and inflammatory diseases
Research activity includes ulcerative colitis, inflammatory bowel disease, psoriasis, atopic dermatitis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, alopecia areata, and dermatomyositis, reflecting a broad focus on chronic immune dysregulation.
- Ulcerative colitis
- Psoriasis
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Sjögren's syndrome
Additional therapeutic interest extends to autoimmune skin disease, systemic inflammation, and immune-mediated muscle and kidney disorders.
Respiratory, hepatic, renal, and ophthalmic disorders
Clinical research also addresses chronic obstructive pulmonary disease, non-cystic fibrosis bronchiectasis, chronic hepatitis B, chronic hepatitis D, hepatic encephalopathy, open-angle glaucoma, ocular hypertension, and retinal vein occlusion, alongside macular degeneration and other retinal conditions.
- Chronic obstructive pulmonary disease
- Chronic hepatitis B
- Hepatic encephalopathy
- Open-angle glaucoma
- Retinal vein occlusion
The therapeutic range includes pulmonary infection control, viral liver disease, intraocular pressure management, and retinal edema.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.