Ton O. O.
- Country
- The Netherlands
- Department
- Research Cardiology
Research Overview
- DUTCH Weight Control in Atrial Fibrillation Study
- Evaluation of Evolocumab on Cardiovascular Outcomes in High-Risk Patients Without Prior Myocardial Infarction or Stroke
- Phase 3 Randomized Double-Blind Placebo-Controlled Study of Intravenous Sodium Iodide (FDY-5301) in Anterior ST-Elevation Myocardial Infarction Patients
Data & Insights
Has run more than one trial at 104 of 506 partner sites.
Specializations
Cardiovascular disease and lipid management
Clinical research activity includes atherosclerotic cardiovascular disease, myocardial infarction, stroke, peripheral arterial disease, and broader cardiovascular risk reduction. The investigator is also involved in studies addressing hypertriglyceridemia, elevated Lp(a), and prevention of recurrent major adverse cardiovascular events.
- ASCVD prevention and secondary risk reduction
- Acute coronary syndromes and ischemic outcomes
- Lipid-lowering therapy and triglyceride disorders
Therapeutic interests also extend to atrial fibrillation, semaglutide-related cardiovascular care, and strategies aimed at reducing vascular events in high-risk populations.
Prostate cancer and advanced uro-oncology
The investigator is active in prostate cancer research spanning high-risk localized disease, metastatic castration-sensitive prostate cancer, and metastatic castration-resistant prostate cancer. Work also includes urothelial carcinoma and other bladder cancer settings.
- Androgen receptor–targeted therapy
- PSMA PET-guided prostate cancer assessment
- Non-muscle-invasive and muscle-invasive bladder cancer
Additional interests include treatment optimization in upper tract urothelial carcinoma and biomarker-informed approaches in advanced genitourinary malignancies.
Hematologic malignancies and cellular therapy combinations
Research involvement covers acute myeloid leukemia, chronic lymphocytic leukemia, small lymphocytic lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, and myelodysplastic syndrome. The clinical focus includes both newly diagnosed and relapsed or refractory disease.
- Leukemia and lymphoma treatment strategies
- Targeted therapy combinations
- Immunotherapy in hematologic cancer
Therapeutic interests also include venetoclax-based regimens, ibrutinib-based approaches, and antibody-directed treatment concepts in aggressive lymphoma.
Respiratory disease, infection, and acute care
The investigator contributes to studies in migraine, asthma, chronic obstructive pulmonary disease, pulmonary sarcoidosis, pneumonia, respiratory tract infection, and acute respiratory distress syndrome. This area also includes hospitalized patients with severe infectious illness and respiratory compromise.
- Severe asthma and eosinophilic airway disease
- Acute respiratory failure and ARDS
- Community-acquired pneumonia and viral respiratory infection
Related interests include supportive care in acute hospitalization and therapies for inflammation-driven respiratory conditions.
Neurology, metabolic disease, and women’s health
Clinical involvement extends to migraine across pediatric and chronic forms, as well as obesity, type 2 diabetes mellitus, and polycystic ovary syndrome. The investigator also participates in studies in infertility and subfertility, alongside selected neurologic and metabolic conditions.
- Pediatric migraine management
- Metabolic disorders and cardiometabolic risk
- Reproductive endocrinology and fertility care
Therapeutic interests further include headache syndromes, conception support, and disease areas where metabolic control intersects with cardiovascular and neurologic outcomes.
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