Tomas S. B.
- Country
- Sweden
- Department
- Childhood cancer center, Astrid Lindgrens Barnsjukhus, Eugeniav. 23, 171 76 Stockholm
Research Overview
- Phase I/II Umbrella Trial of Ulixertinib, Tovorafenib, and Vinblastine Sulfate in Pediatric Patients with Progressive, Relapsed, or Refractory Low-Grade Glioma
- Phase 3 Randomized Trial of Tovorafenib Monotherapy vs. Standard Chemotherapy in Pediatric Low-Grade Glioma with RAF Alteration
- Long-term Safety Assessment of Dabrafenib Mesylate and Trametinib in Pediatric Patients with Cancers Harboring V600 Mutation: A Multi-center Roll-over Study
Data & Insights
Has run more than one trial at 22 of 61 partner sites.
Specializations
Pediatric Oncology and Hematologic Malignancies
The clinical research profile includes a strong focus on childhood cancer, especially acute lymphoblastic leukemia, acute myeloid leukemia, lymphoma, and other high-risk pediatric malignancies. Activity also extends to relapsed and refractory disease, with attention to treatment options for aggressive blood cancers and solid tumors in children and adolescents.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Diffuse large B-cell lymphoma
- Neuroblastoma
- Medulloblastoma
Research interests also include stem cell transplantation, minimal residual disease, and therapies for relapsed/refractory leukemia and lymphoma in the pediatric setting.
Neuro-oncology and Rare Central Nervous System Tumors
The investigator is involved in studies of brain tumors, with emphasis on glioblastoma, diffuse midline glioma, pediatric low-grade glioma, and other rare central nervous system malignancies. This area reflects a therapeutic interest in difficult-to-treat tumors with limited standard options.
- Glioblastoma
- Diffuse midline glioma
- Pediatric low-grade glioma
- Medulloblastoma
- Atypical teratoid/rhabdoid tumor
Clinical work in this domain also includes cognitive outcomes and tumor-directed immunotherapy for selected neurologic cancers.
Autoimmune, Inflammatory, and Immune-Mediated Diseases
Another major therapeutic area covers autoimmune disease and chronic immune-mediated inflammation, including rheumatoid arthritis, systemic lupus erythematosus, Crohn's disease, ulcerative colitis, and psoriatic arthritis. The portfolio also includes conditions affecting the skin, joints, kidneys, and lungs.
- Systemic lupus erythematosus
- Rheumatoid arthritis
- Crohn's disease
- Ulcerative colitis
- Psoriatic arthritis
Related interests include myositis, multiple sclerosis, myasthenia gravis, and immune checkpoint inhibitor-related arthritis.
Renal, Transplant, and Urologic Disorders
The research landscape also includes kidney disease, renal transplantation, and urologic cancer, with attention to proteinuria, glomerular disease, kidney failure, and transplant rejection. This domain connects chronic organ disease with advanced therapeutic strategies.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- Kidney transplant rejection
- Renal cell carcinoma
- Urothelial carcinoma
Additional interests include chronic kidney disease, end-stage kidney disease, and prostate cancer.
Solid Tumors, Targeted Therapy, and Immuno-Oncology
The investigator participates in trials across a broad range of adult and pediatric solid tumors, including breast cancer, lung cancer, ovarian cancer, colorectal cancer, pancreatic cancer, and melanoma. The therapeutic focus includes targeted therapy, immune checkpoint inhibition, and treatment approaches for advanced or metastatic disease.
- Breast cancer
- Non-small cell lung cancer
- Ovarian cancer
- Colorectal cancer
- Melanoma
Research activity also spans gastrointestinal cancers, prostate cancer, urothelial cancer, and molecularly targeted oncology.
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