Tomáš R.
- Country
- Czechia
- Department
- Klinika radiologie a nukleární medicíny
Research Overview
- (21181) A multicenter, randomized, prospective double-blind, cross over Phase 3 study to evaluate the efficacy and safety of 0.04 mmol Gd/kg body weight of gadoquatrane for MRI in adults with known or suspected pathology of the central nervous system (CNS), compared to 0.1 mmol Gd/kg approved macrocyclic gadolinium-based contrast agents (GBCAs)
- (21197) A multicenter, randomized, prospective double-blind, cross over Phase 3 study to evaluate the efficacy and safety of 0.04 mmol Gd/kg body weight of gadoquatrane for MRI in adults with known or suspected pathology of any body region (except CNS), compared to 0.1 mmol Gd/kg approved macrocyclic gadolinium-based contrast agents (GBCAs)
Data & Insights
Has run more than one trial at 20 of 52 partner sites.
Specializations
Hematologic malignancies
Clinical activity includes a broad focus on acute myeloid leukemia, acute lymphoblastic leukemia, chronic lymphocytic leukemia, multiple myeloma, and lymphoma, with additional interest in related myelodysplastic syndromes and other marrow disorders.
- Leukemia and lymphoma
- Multiple myeloma
- Myelodysplastic syndromes
The therapeutic landscape also extends to relapsed and refractory blood cancers, pediatric hematologic malignancies, and post-transplant disease control.
Cardiovascular medicine
Research involvement spans acute myocardial infarction, heart failure, atherosclerotic cardiovascular disease, prevention of stroke, and broader thromboembolic and vascular risk settings.
- Acute coronary syndromes
- Heart failure
- Thrombotic risk
Additional interest includes anticoagulation reversal, cardiovascular event reduction, and management of high-risk cardiometabolic profiles.
Respiratory and sleep disorders
Clinical trial activity covers asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, refractory chronic cough, and obstructive sleep apnea.
- Asthma
- COPD
- Sleep-disordered breathing
The respiratory portfolio also includes severe eosinophilic disease, viral lung infection prevention, and chronic inflammatory airway conditions.
Autoimmune, inflammatory, and rare immune-mediated disease
Areas of interest include multiple sclerosis, myasthenia gravis, inflammatory bowel disease, psoriasis, atopic dermatitis, uveitis, and immune thrombocytopenia.
- Neurologic autoimmunity
- Inflammatory bowel disease
- Dermatologic inflammation
Therapeutic interest also reaches rare immune dysregulation, complement-related disorders, and systemic inflammatory syndromes.
Solid tumors and pediatric oncology
Trial involvement includes breast cancer, lung cancer, ovarian cancer, endometrial cancer, renal cell carcinoma, pancreatic cancer, and cervical cancer, together with pediatric tumors such as medulloblastoma, neuroblastoma, and sarcoma.
- Solid tumors
- Pediatric cancers
- Gynecologic oncology
The oncology scope also includes metastatic disease, biomarker-defined malignancies, and advanced cancer settings requiring novel therapeutic strategies.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.