Tom V. M.
- Country
- The Netherlands
- Department
- Hematology
Research Overview
- Safety and Dosing Evaluation of KITE-363 and KITE-753 in Relapsed/Refractory B-cell Lymphoma Patients
- Efficacy Evaluation of Brexucabtagene Autoleucel in Relapsed/Refractory Mantle Cell Lymphoma: A Phase 2 Multicenter Study
- Early treatment intensification in patients with high risk Mantle Cell Lymphoma using CAR-T-cell treatment after an abbreviated induction therapy with Rituximab and Ibrutinib and 6 months Ibrutinib maintenance (Arm A) as compared to standard of care induction and maintenance (Arm B)
Data & Insights
Has run more than one trial at 68 of 213 partner sites.
Specializations
Hematologic Malignancies and Cellular Therapy
Clinical work in diffuse large B-cell lymphoma, high-risk large B-cell lymphoma, Hodgkin lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, multiple myeloma, and other relapsed/refractory B-cell malignancies reflects a strong focus on blood cancers and treatment resistance. The portfolio also includes myelodysplastic syndrome, myelofibrosis, mantle cell lymphoma, and small lymphocytic lymphoma.
- Diffuse large B-cell lymphoma
- Acute myeloid leukemia
- Multiple myeloma
- Relapsed/refractory lymphoma
- Myelodysplastic syndrome
Research activity in this area is closely linked to immunotherapy, CAR T-cell therapy, and other advanced hematology-focused treatment strategies.
Solid Tumors in Thoracic, Gastrointestinal, and Genitourinary Oncology
The investigator is involved in studies of non-small cell lung cancer, small cell lung cancer, head and neck squamous cell carcinoma, esophageal cancer, gastric cancer, colorectal cancer, pancreatic cancer, hepatocellular carcinoma, and biliary tract cancer. Additional interests include prostate cancer, urothelial cancer, ovarian cancer, endometrial cancer, and melanoma.
- Non-small cell lung cancer
- Head and neck squamous cell carcinoma
- Colorectal cancer
- Prostate cancer
- Ovarian cancer
These oncology studies span both locally advanced disease and metastatic solid tumors, with a clear emphasis on targeted and immune-based cancer treatment.
Renal, Transplant, and Immune-Mediated Disorders
Research interests include chronic kidney disease, IgA nephropathy, autosomal dominant polycystic kidney disease, kidney transplant rejection, proteinuria, and kidney failure. The portfolio also extends to anti-GBM antibody disease, immune complex membranoproliferative glomerulonephritis, and focal segmental glomerulosclerosis.
- Chronic kidney disease
- IgA nephropathy
- Kidney transplant rejection
- Autosomal dominant polycystic kidney disease
- Anti-GBM antibody disease
This area also includes renal transplantation and immunologic kidney disease, supporting innovation in kidney preservation and transplant-related care.
Autoimmune, Inflammatory, and Dermatologic Disease
The investigator is active in rheumatoid arthritis, systemic lupus erythematosus, Sjögren’s disease, systemic sclerosis, polymyalgia rheumatica, vasculitis, and IgG4-related disease. Dermatologic interests include hidradenitis suppurativa, atopic dermatitis, bullous pemphigoid, psoriasis, prurigo nodularis, and pruritus.
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Hidradenitis suppurativa
- Atopic dermatitis
- IgG4-related disease
Work in this domain also covers immune-mediated inflammation and autoimmune skin disease, with attention to chronic symptom burden and disease control.
Cardiovascular, Pulmonary, and Critical Care Medicine
Clinical activity includes heart failure, atrial fibrillation, myocardial infarction, pulmonary arterial hypertension, chronic obstructive pulmonary disease, interstitial lung disease, and acute respiratory distress syndrome. Additional areas include cardiovascular disease, stroke, and critical illness.
- Heart failure
- Atrial fibrillation
- Pulmonary arterial hypertension
- Chronic obstructive pulmonary disease
- Acute respiratory distress syndrome
These studies align with interest in cardiorenal risk, inflammatory cardiovascular disease, and respiratory failure management.
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