Tobias W.
- Country
- Germany
- Department
- Klinik für Kinder- und Jugendmedizin
Research Overview
- A Phase 3, Multicenter, Open-label, Basket, Long-term Extension Study of Ustekinumab in Pediatric Clinical Study Participants (2 to <18 Years of Age)
- Evaluation of Filgotinib Efficacy, Safety, and Pharmacokinetics in Pediatric Patients with Moderate to Severe Ulcerative Colitis
- Efficacy, Safety, and Pharmacokinetics of Ustekinumab in Pediatric Patients with Moderate to Severe Crohn's Disease: A Phase 3 Randomized Controlled Trial
Data & Insights
Has run more than one trial at 29 of 188 partner sites.
Specializations
Pediatric Hematology and Leukemia
Clinical research in acute lymphoblastic leukemia, acute myeloid leukemia, myelodysplastic syndromes, and related myeloid neoplasms is a central area of interest, with attention to treatment options for children and adolescents.
- Acute lymphoblastic leukemia
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Myeloproliferative neoplasms
The investigator is also involved in studies addressing stem cell transplantation and graft-versus-host disease in pediatric blood cancers.
Pediatric Oncology and Solid Tumors
Another major focus is the treatment of pediatric solid tumors, including neuroblastoma, Ewing sarcoma, medulloblastoma, and rhabdomyosarcoma, as well as other rare childhood malignancies.
- Neuroblastoma
- Ewing sarcoma
- Medulloblastoma
- Rhabdomyosarcoma
Research activity also includes germ cell tumors, brain tumors, and head and neck cancers in younger patients.
Transplantation and Immune-Mediated Disorders
The investigator contributes to clinical studies in allogeneic transplantation, transplant rejection prophylaxis, and immune complications such as chronic graft-versus-host disease and acute graft-versus-host disease.
- Allogeneic stem cell transplantation
- Graft-versus-host disease
- Transplant rejection
- Immune thrombocytopenia
Therapeutic interest extends to autoimmune disease and systemic inflammatory disorders affecting hematology and pediatrics.
Pediatric Gastroenterology and Inflammatory Disease
Clinical trial involvement also covers inflammatory bowel disease, especially ulcerative colitis and Crohn's disease, along with other chronic immune-mediated conditions in children.
- Ulcerative colitis
- Crohn's disease
- Atopic dermatitis
- Chronic spontaneous urticaria
There is also interest in broader pediatric inflammatory skin disease and autoimmune glomerular disease.
Cardiorenal and Neurologic Therapeutics
Additional research spans cardiovascular disease, heart failure, stroke prevention, and kidney disease, reflecting involvement in therapies for systemic complications and organ protection.
- Heart failure
- Chronic kidney disease
- Ischemic stroke
- Epilepsy
Research activity further includes seizure disorders, atherosclerotic cardiovascular disease, and metabolic and renal complications in pediatric and adult populations.
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