Tobias S.
- Country
- Germany
- Department
- Klinik für Urologie
Research Overview
- Phase 3 Randomized Open-label Study of Belzutifan and Zanzalintinib Versus Cabozantinib in Advanced Renal Cell Carcinoma Post Anti-PD-1/L1 Therapy
- Phase III Randomized, Double-Blind, Placebo-Controlled Study of Saruparib (AZD5305) with Radiotherapy and Androgen Deprivation Therapy in BRCAm High-Risk Prostate Cancer
Data & Insights
Has run more than one trial at 28 of 163 partner sites.
Specializations
Urologic Oncology
Clinical research in prostate cancer includes treatment approaches for metastatic castration-resistant prostate cancer and high-risk localized or locally advanced prostate cancer, with interest in molecularly defined disease such as BRCA-mutated and BRAF V600-relevant settings. The portfolio also extends to renal cell carcinoma and broader kidney cancer studies.
- Prostate Cancer
- Metastatic Castration-Resistant Prostate Cancer
- Renal Cell Carcinoma
- High-Risk Prostate Cancer
- BRCA-Mutated Disease
Interest in this area centers on advanced genitourinary malignancies and biomarker-driven treatment options.
Hematologic Malignancies
Research activity includes childhood and adult acute lymphoblastic leukemia, lymphoblastic lymphoma, and relapsed or high-risk disease, with additional involvement in germ cell tumors and other aggressive hematologic cancers. The clinical focus includes Philadelphia chromosome-positive ALL and relapsed ALL populations.
- Acute Lymphoblastic Leukemia
- Lymphoblastic Lymphoma
- Relapsed ALL
- Philadelphia Chromosome-Positive ALL
- Malignant Germ Cell Tumours
These studies reflect involvement in complex blood cancers across pediatric and adult oncology.
Neuro-Oncology
The investigator is involved in trials for medulloblastoma, ependymoma, and glioma, including high-risk and newly diagnosed disease. This area also includes studies aimed at improving outcomes in intracranial and spinal tumors in children, adolescents, and adults.
- Medulloblastoma
- Ependymoma
- Glioma
- High-Risk Central Nervous System Tumors
- Pediatric Brain Tumors
Clinical interest in this field spans rare neuro-oncologic diseases with substantial therapeutic need.
Immune-Mediated and Inflammatory Diseases
Trial involvement covers plaque psoriasis, rheumatoid arthritis, thyroid eye disease, and Graves’ disease, alongside other inflammatory conditions such as polymyalgia rheumatica. The portfolio also includes chronic venous ulcers and related wound-healing indications.
- Plaque Psoriasis
- Rheumatoid Arthritis
- Thyroid Eye Disease
- Graves’ Disease
- Chronic Venous Ulcers
Work in this domain is centered on immune modulation and treatment of persistent inflammatory disorders.
Metabolic, Cardiovascular, and Symptom-Driven Disorders
Additional research interests include atrial fibrillation, heart failure, atherosclerotic cardiovascular disease, hyperlipidemia, and type 2 diabetes mellitus. The investigator is also engaged in symptom-focused studies involving migraine, insomnia disorder, major depressive disorder, chronic pain, irritable bowel syndrome, and alcohol use disorder.
- Atrial Fibrillation
- Heart Failure
- Type 2 Diabetes Mellitus
- Major Depressive Disorder
- Chronic Pain and Migraine Disorders
This range shows involvement in cardiometabolic care and therapies addressing chronic symptoms and quality-of-life burden.
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