Tim D. M.
- Country
- The Netherlands
- Department
- Kindergeneeskunde
Research Overview
- An Observational Study of Methotrexate Pharmacokinetics and Pharmacodynamics in Paediatric and Adolescent Patients with Crohn’s Disease
- Open-Label Induction and Maintenance Study of Oral Tofacitinib in Pediatric Patients with Moderately to Severely Active Ulcerative Colitis
- Pharmacokinetic Evaluation of Infliximab in Pediatric Patients with Crohn's Disease: A Prospective Analysis
Data & Insights
Has run more than one trial at 2 of 37 partner sites.
Specializations
Pediatric Gastroenterology and Intestinal Disorders
Clinical research activity includes functional constipation, intestinal malabsorption, and inflammatory bowel disease with a focus on Crohn's disease, ulcerative colitis, and complex perianal fistula care in children.
- Functional constipation
- Intestinal malabsorption
- Crohn's disease
- Ulcerative colitis
- Perianal fistula
Interest also extends to eosinophilic esophagitis and other chronic digestive conditions affecting pediatric patients.
Childhood Respiratory and Neonatal Care
Work spans chronic lung disease of prematurity, bronchiectasis, cystic fibrosis, and severe asthma, alongside neonatal conditions such as apnea of prematurity and severe bronchopulmonary dysplasia.
- Chronic lung disease
- Bronchiectasis
- Cystic fibrosis
- Severe asthma
- Bronchopulmonary dysplasia
Research also touches on hyperbaric oxygen therapy for acute hearing injury and broader respiratory support in early life.
Pediatric Neurology and Neurodevelopment
Investigations include cerebral palsy, epilepsy, leukoencephalopathy, developmental disorders, and rare inherited conditions such as Fragile X syndrome and Tuberous Sclerosis Complex.
- Cerebral palsy
- Epilepsy
- Leukoencephalopathy
- Fragile X syndrome
- Tuberous Sclerosis Complex
Additional activity involves neurodevelopmental impairment and pediatric cognitive disorders.
Pediatric Endocrine and Metabolic Conditions
Clinical interest covers type 1 diabetes, type 2 diabetes, obesity, overweight, and polycystic ovary syndrome, with attention to metabolic regulation in children and adolescents.
- Type 1 diabetes
- Type 2 diabetes
- Obesity
- Overweight
- Polycystic ovary syndrome
Research also includes growth-related endocrine disorders and metabolic dysfunction in pediatric care.
Pediatric Hepatology, Immunology, and Rare Disease
Areas of involvement include primary sclerosing cholangitis, primary biliary cholangitis, autoimmune disease, hereditary angioedema, and rare genetic disorders such as phenylketonuria and osteogenesis imperfecta.
- Primary sclerosing cholangitis
- Primary biliary cholangitis
- Autoimmune disease
- Hereditary angioedema
- Rare genetic disorders
Therapeutic interest also covers pruritus, immune-mediated inflammation, and pediatric rare disease management.
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