Till O.
- Country
- Germany
- Department
- Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine
Research Overview
Data & Insights
Has run more than one trial at 0 of 13 partner sites.
Specializations
Pediatric Respiratory and Critical Care
Focused on life‑threatening pulmonary conditions in children, including severe infections and ventilatory failure.
- Acute Respiratory Distress Syndrome
- Bronchiectasis with chronic Pseudomonas colonization
- Severe community‑acquired pneumonia
- Respiratory syncytial virus infection
- Critical illness requiring mechanical ventilation
Research integrates advanced ventilatory strategies and immunomodulatory support to improve outcomes in pediatric critical care settings.
Autoimmune and Systemic Inflammatory Disorders
Investigates mechanisms and therapies for multisystem autoimmune diseases that affect children and adolescents.
- Systemic Lupus Erythematosus
- ANCA‑associated vasculitis
- Immune thrombocytopenia
- Juvenile idiopathic inflammatory myopathy
- Chronic spontaneous urticaria
Efforts emphasize targeted biologics and cytokine inhibition to restore immune homeostasis in autoimmune disease cohorts.
Pediatric Oncology and Hematology
Addresses malignant hematologic and solid tumours prevalent in the pediatric population.
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
- Neuroblastoma
- High‑risk B‑cell non‑Hodgkin lymphoma
- Medulloblastoma
Clinical programs explore molecularly guided therapies and immunotherapeutic approaches for pediatric malignancies.
Transplantation and Immunological Tolerance
Focuses on immune modulation to prevent rejection and treat graft‑versus‑host disease.
- Kidney transplant rejection
- Chronic graft‑versus‑host disease
- Antibody‑mediated rejection
- Allogeneic hematopoietic stem cell transplantation
- Immunosuppressive therapy optimization
Studies aim to achieve durable immune tolerance while minimizing infection risk.
Rare Genetic and Metabolic Disorders
Investigates inherited conditions with multisystem impact, often requiring specialized therapeutic strategies.
- Alport syndrome
- Fabry disease
- Hereditary angioedema
- Autosomal dominant polycystic kidney disease
- Primary sclerosing cholangitis
Efforts include enzyme replacement, gene‑targeted therapies, and supportive care to improve quality of life in rare disease patients.
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