Theo L.
- Country
- Germany
- Department
- 276001; Klinik fuer Haematologie und Onkologie
Research Overview
- AN OPEN-LABEL, RANDOMIZED, PHASE 3 STUDY OF LINVOSELTAMAB (REGN5458; ANTI-BCMA X ANTI-CD3 BISPECIFIC ANTIBODY) VERSUS THE COMBINATION OF ELOTUZUMAB, POMALIDOMIDE, AND DEXAMETHASONE (EPd), IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (LINKER-MM3)
- Phase III Evaluation of Elotuzumab with Carfilzomib, Lenalidomide, and Dexamethasone in Newly Diagnosed Multiple Myeloma Post-Autologous Stem Cell Transplant
- Evaluation of Isatuximab, Evorpacept, and Dexamethasone in Relapsed or Refractory Multiple Myeloma: A Phase 1/2 Clinical Trial
Data & Insights
Has run more than one trial at 26 of 149 partner sites.
Specializations
Haematologic malignancies and stem cell transplantation
Clinical research interests include acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, chronic lymphocytic leukemia, multiple myeloma, and lymphoma, with a strong emphasis on allogeneic hematopoietic stem cell transplantation and graft-versus-host disease.
- Acute myeloid leukemia
- Myelodysplastic syndromes
- Chronic lymphocytic leukemia
- Multiple myeloma
- Graft-versus-host disease
Research activity also extends to relapsed or refractory disease, high-risk myeloid neoplasms, and transplant-related outcomes in patients receiving intensive hematologic care.
Solid tumors and oncologic immunotherapy
The investigator is involved in studies across lung cancer, breast cancer, melanoma, gastrointestinal cancers, urothelial carcinoma, prostate cancer, and head and neck cancer, with interest in immune checkpoint and other targeted therapies.
- Non-small cell lung cancer
- Breast cancer
- Melanoma
- Hepatocellular carcinoma
- Urothelial carcinoma
Additional focus includes biomarker-defined malignancies, advanced metastatic disease, and treatment strategies for solid tumors requiring multimodal oncologic management.
Autoimmune and inflammatory diseases
Therapeutic interests include systemic lupus erythematosus, lupus nephritis, Crohn's disease, ulcerative colitis, psoriasis, atopic dermatitis, and hidradenitis suppurativa, alongside other immune-mediated disorders.
- Systemic lupus erythematosus
- Lupus nephritis
- Inflammatory bowel disease
- Psoriasis
- Atopic dermatitis
Research also covers bullous pemphigoid, vasculitis, and systemic sclerosis, reflecting involvement in chronic inflammatory and autoimmune therapeutic areas.
Cardiovascular, renal, and metabolic disorders
Clinical interests include atrial fibrillation, acute coronary syndromes, heart failure, atherosclerotic cardiovascular disease, chronic kidney disease, IgA nephropathy, and kidney transplantation.
- Atrial fibrillation
- Heart failure
- Chronic kidney disease
- IgA nephropathy
- Kidney transplantation
Work also includes hyperlipidemia, obesity, prediabetes, and metabolic dysfunction-associated steatohepatitis, linking cardiometabolic risk with organ-specific disease management.
Neurologic, respiratory, and critical care conditions
The investigator is also active in studies of acute ischemic stroke, amyotrophic lateral sclerosis, Parkinson's disease, epilepsy, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and sepsis.
- Acute ischemic stroke
- Amyotrophic lateral sclerosis
- Parkinson's disease
- Idiopathic pulmonary fibrosis
- Sepsis
Additional research areas include intensive care, post-COVID inflammatory complications, and neuropathic pain, broadening the therapeutic scope beyond oncology and immunology.
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