Than van France N.
- Country
- France
- Department
- Radiotherapy
Research Overview
- Phase II Study of JNJ-90301900 in Combination with Concurrent Chemoradiotherapy in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma
- Phase II Evaluation of Durvalumab Combined with Radiotherapy in T1-T4 N0-N2b Squamous Cell Carcinoma of the Head and Neck Without Prophylactic Neck Irradiation
Data & Insights
Has run more than one trial at 3 of 22 partner sites.
Specializations
Hematologic Oncology
Clinical investigation of high‑risk myeloid neoplasms with a focus on disease‑specific biology and therapeutic resistance.
- Acute Myeloid Leukemia (AML)
- Myelodysplastic Syndromes (MDS)
- Chronic Myelomonocytic Leukemia (CMML)
- Acute Lymphoblastic Leukemia (ALL) in adults
- Acute Graft‑Versus‑Host Disease
Research is conducted at the Institut Gustave Roussy, integrating advanced radiotherapeutic approaches for marrow‑directed treatment.
Molecularly Targeted Solid Tumors
Exploration of genomic alterations that drive tumor growth and guide precision‑medicine strategies.
- MTAP‑deleted solid cancers
- KRAS G12C mutant tumors
- HER2‑mutated and HER2‑low malignancies
- FGFR2b overexpressing cancers
- TP53 Y220C altered neoplasms
These studies prioritize biomarker‑driven enrollment to assess novel targeted agents within a multidisciplinary oncology program.
Thoracic Oncology
Focused trials on malignancies of the chest cavity, emphasizing both histologic and molecular subtypes.
- Non‑Small Cell Lung Cancer (NSCLC)
- Small Cell Lung Cancer (SCLC)
- Mesothelioma
- ALK‑positive lung tumors
- EGFR‑mutated NSCLC
Radiotherapy protocols are integrated to evaluate synergistic effects with emerging systemic therapies.
Gynecologic and Breast Oncology
Investigation of hormone‑driven and HPV‑related cancers affecting female patients.
- Hormone Receptor‑positive Breast Cancer
- Triple‑Negative Breast Cancer (TNBC)
- Endometrial Carcinoma
- Cervical Squamous Cell Carcinoma
- Ovarian Carcinoma with high‑grade serous histology
Trial designs incorporate adjuvant and neoadjuvant radiotherapy to improve local control and survival outcomes.
Radiotherapy Innovation
Development of advanced radiation techniques combined with systemic agents for refractory and localized disease.
- Stereotactic Ablative Radiotherapy (SABR)
- Intensity‑Modulated Radiotherapy (IMRT)
- Proton Beam Therapy
- Radio‑Sensitizing Agents
- Radiodermatitis Management
These efforts aim to enhance therapeutic ratios for both solid and hematologic malignancies within the radiotherapy department.
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