Sylvestre L. M. S.
- Country
- France
- Department
- oncology
Research Overview
Data & Insights
Has run more than one trial at 0 of 117 partner sites.
Specializations
Hematologic malignancies
The investigator is involved in clinical research across myelodysplastic syndromes, multiple myeloma, chronic myeloid leukemia, chronic lymphocytic leukemia, follicular lymphoma, and myeloproliferative neoplasms, with additional interest in chronic myelomonocytic leukemia.
- Myelodysplastic syndromes
- Multiple myeloma
- Leukemia and lymphoma
- Myeloproliferative neoplasms
Research activity also includes treatment strategies for transfusion-related anemia, transplant-ineligible disease, and minimal residual disease assessment in blood cancers.
Breast and endocrine oncology
Clinical work in breast cancer spans early-stage hormone receptor-positive disease, ER+/HER2- metastatic breast cancer, and low-risk luminal A phenotypes, alongside studies of endocrine-based treatment approaches.
- Early breast cancer
- Metastatic breast cancer
- Endocrine therapy
- Luminal A disease
The therapeutic focus includes adjuvant and maintenance strategies, treatment de-escalation in selected patients, and biomarker-guided adaptation of endocrine therapy.
Solid tumors
The investigator is active in trials for non-small cell lung cancer, renal cell carcinoma, prostate cancer, colon cancer, colorectal cancer, and endometrial cancer, including advanced and metastatic settings.
- Non-small cell lung cancer
- Renal cell carcinoma
- Prostate cancer
- Colorectal and endometrial cancer
Areas of interest also include immunotherapy, androgen receptor pathway targeting, and postoperative relapse prevention in high-risk solid tumors.
Autoimmune and vascular disorders
Research involvement extends beyond oncology to ANCA vasculitis, systemic sclerosis, Raynaud phenomenon, and vascular prevention in patients with inflammatory or thrombotic risk.
- ANCA vasculitis
- Systemic sclerosis
- Raynaud phenomenon
- Thrombotic prevention
Therapeutic interest includes immunosuppression management in renal disease, antiplatelet strategies, and prevention of vascular complications in chronic inflammatory conditions.
Supportive care and non-oncologic conditions
The investigator also contributes to studies in migraine, type 1 diabetes mellitus, infectious disease, sepsis, and cardiovascular disease, reflecting a broader clinical research profile.
- Migraine
- Type 1 diabetes mellitus
- Sepsis and bloodstream infection
- Cardiovascular and cerebrovascular disease
These activities include symptom control, infection treatment, and prevention of organ-threatening complications in acute and chronic medical settings.
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