Stoil B.
- Country
- Bulgaria
- Department
- Medical Oncology Level II
Research Overview
- Phase III Randomized Study of Hetrombopag Olamine Efficacy and Safety in Patients with Chemotherapy-Induced Thrombocytopenia
- Pumitamig Versus Durvalumab After Concurrent Chemoradiation in Unresectable Stage III Non-Small Cell Lung Cancer Without Progression
- Phase 2 Randomized Double-Blind Placebo-Controlled Study of Ponsegromab in Cancer Cachexia with Elevated GDF-15 Concentrations
Data & Insights
Has run more than one trial at 355 of 686 partner sites.
Specializations
Medical Oncology and Solid Tumors
Clinical research activity centers on advanced solid tumors, with strong involvement in breast cancer, non-small cell lung cancer, colorectal cancer, ovarian cancer, gastric cancer, and head and neck squamous cell carcinoma. The portfolio also includes melanoma, endometrial cancer, urothelial carcinoma, and pancreatic cancer.
- Breast cancer and triple-negative breast cancer
- Non-small cell lung cancer and small cell lung cancer
- Colorectal cancer and gastrointestinal malignancies
- Gynecologic cancers and urothelial cancer
Research interests also extend to biomarker-defined and molecularly selected malignancies, including HER2-directed, EGFR-related, KRAS-mutated, and PIK3CA-mutated disease.
Hematologic Malignancies
The investigator is actively involved in studies of acute myeloid leukemia, myelodysplastic syndrome, myelofibrosis, multiple myeloma, and lymphoma subtypes, including diffuse large B-cell lymphoma, mantle cell lymphoma, follicular lymphoma, and chronic lymphocytic leukemia. The portfolio also includes relapsed/refractory hematologic disease and transplant-related settings.
- Acute myeloid leukemia and myelodysplastic syndrome
- Multiple myeloma
- Large B-cell lymphoma and mantle cell lymphoma
- Myelofibrosis and chronic lymphocytic leukemia
Key therapeutic interests include CAR T-cell therapy, autologous transplantation, and treatment strategies for minimal residual disease and refractory hematologic cancers.
Cardiovascular and Thrombotic Disorders
Research activity includes acute coronary syndrome, myocardial infarction, heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, stroke, and resistant hypertension. The investigator also participates in studies addressing cardiometabolic risk and cardiorenal disease.
- Heart failure and cardiomyopathy
- Atrial fibrillation and stroke prevention
- Acute myocardial infarction and acute coronary syndrome
- Chronic kidney disease with cardiovascular risk
Therapeutic focus also covers anticoagulation reversal, thromboembolic prevention, and inflammatory pathways linked to cardiovascular events.
Autoimmune, Inflammatory, and Respiratory Diseases
The clinical portfolio includes rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, Crohn’s disease, ulcerative colitis, atopic dermatitis, hidradenitis suppurativa, and polymyalgia rheumatica. Respiratory interests include chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, and pulmonary sarcoidosis.
- Autoimmune rheumatic disease
- Inflammatory bowel disease
- Atopic and dermatologic inflammation
- Chronic respiratory disease
Additional work includes multiple sclerosis, myasthenia gravis, and other immune-mediated conditions requiring targeted anti-inflammatory treatment approaches.
Neuroscience, Infectious Disease, and Metabolic-Liver Disorders
Research interests also span Alzheimer’s disease, Parkinson’s disease, migraine, epilepsy, depression, and psychosis, alongside infectious disease topics such as COVID-19, influenza, Clostridioides difficile infection, and respiratory viral infections. Metabolic and liver-related studies include nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, cirrhosis, and hepatocellular carcinoma.
- Neurodegenerative and psychiatric disorders
- Viral and bacterial infections
- Steatotic liver disease and cirrhosis
- Hepatocellular carcinoma
Therapeutic activity includes research in neurologic symptom control, anti-infective treatment, and liver-directed therapy for progressive chronic disease.
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