Stéphane B.
- Country
- France
- Department
- Nephrology
Research Overview
- A Phase 3 open-label, controlled, randomised, multi-centre trial comparing imlifidase and standard-of-care with standard-of-care alone in the treatment of severe anti-GBM antibody disease (Goodpasture disease)
- THINK - intensification of blood pressure lowering Therapeutics based on diuretics versus usual management for uncontrolled Hypertension IN patients with moderate to severe chronic Kidney disease: an open label, cluster randomized controlled, phase 3 trial
- Evaluation of Pegcetacoplan for Reducing Proteinuria in Adults and Adolescents with Focal Segmental Glomerulosclerosis
Data & Insights
Has run more than one trial at 235 of 558 partner sites.
Specializations
Nephrology and Kidney Disease
Clinical research includes a strong focus on chronic kidney disease, glomerular disease, and renal transplantation, with activity across conditions affecting native and transplanted kidneys.
- IgA nephropathy
- Focal segmental glomerulosclerosis
- APOL1-mediated proteinuric kidney disease
- Kidney transplantation
- Autosomal dominant polycystic kidney disease
Additional interests extend to lupus nephritis, anti-GBM disease, ANCA-associated vasculitis, and kidney complications linked to systemic inflammatory disorders.
Autoimmune and Inflammatory Diseases
The investigator is engaged in therapeutic research for immune-mediated disorders affecting the kidneys, lungs, joints, and connective tissues, with emphasis on conditions requiring targeted immunomodulation.
- ANCA-associated vasculitis
- Systemic lupus erythematosus
- Crohn’s disease
- Ulcerative colitis
- Rheumatoid arthritis
Research activity also includes giant cell arteritis, Sjögren’s syndrome, systemic sclerosis, and dermatomyositis, reflecting a broad interest in chronic immune dysregulation.
Pulmonary and Respiratory Medicine
Clinical trial involvement covers major respiratory disorders, including obstructive, inflammatory, infectious, and fibrotic lung diseases, as well as pulmonary vascular conditions.
- Severe asthma
- Chronic obstructive pulmonary disease
- Idiopathic pulmonary fibrosis
- Pulmonary hypertension
- Bronchiectasis
Additional therapeutic interests include chronic pulmonary aspergillosis, systemic sclerosis-associated interstitial lung disease, and progressive pulmonary fibrosis.
Cardiovascular and Thrombotic Disorders
Research activities span cardiovascular risk reduction, arrhythmia prevention, myocardial injury, and thromboembolic disease, with attention to both acute and chronic cardiovascular settings.
- Myocardial infarction
- Heart failure
- Atherosclerotic cardiovascular disease
- Venous thromboembolism
- Cardiomyopathy
Further involvement includes acute ischemic stroke, out-of-hospital cardiac arrest, hypertrophic cardiomyopathy, and atrial arrhythmia.
Oncology and Hematologic Malignancies
The investigator also contributes to clinical research in solid tumors and blood cancers, with a therapeutic interest in advanced malignancies, molecularly defined cancers, and rare oncologic diseases.
- Non-small cell lung cancer
- Head and neck squamous cell carcinoma
- Renal cell carcinoma
- Acute lymphoblastic leukemia
- Glioblastoma
Additional areas include melanoma, gastrointestinal stromal tumor, small cell lung cancer, and lymphoma.
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