Stefano F.
- Country
- Italy
- Department
- Gastroenterology
Research Overview
- Phase 3 Randomized Double‑Blind Placebo‑Controlled Study of Efimosfermin Alfa in Adults with Biopsy‑Confirmed F2–F3 Metabolic Dysfunction‑Associated Steatohepatitis
- Phase 3 Randomized Double‑Blind Placebo‑Controlled Study of Efimosfermin Alfa Safety and Tolerability in Adults with F2‑F3 Metabolic Dysfunction‑Associated Steatohepatitis
- A phase III, multicenter, randomized, open-label trial to evaluate the safety and efficacy of systemic therapy with regorafenib and pembrolizumab, versus locoregional therapy with transarterial chemoembolization (TACE) or transarterial radioembolization (TARE), for the first-line treatment of intermediate-stage hepatocellular carcinoma with beyond up-to-7 criteria (REPLACE).
Data & Insights
Has run more than one trial at 148 of 238 partner sites.
Specializations
Gastroenterology and Hepatology
Clinical research activity in inflammatory bowel disease, Crohn's disease, ulcerative colitis, cholestatic pruritus, and chronic hepatitis B and hepatitis D reflects a strong therapeutic focus on digestive and liver disorders. The portfolio also includes metabolic dysfunction-associated steatotic liver disease, nonalcoholic steatohepatitis, alcohol-related liver disease, hepatocellular carcinoma, and biliary atresia.
- Inflammatory bowel disease
- Cholestatic liver disease
- Chronic viral hepatitis
- Metabolic liver disease
- Hepatocellular carcinoma
Therapeutic interests extend to liver-directed care, symptom control in cholestatic conditions, and medical innovation in chronic hepatic and intestinal disease.
Cardiovascular and Thrombotic Disease
Research involvement covers heart failure with reduced or preserved ejection fraction, atrial fibrillation, acute coronary syndrome, myocardial infarction, stroke, and venous thromboembolism. Additional activity includes atherosclerotic cardiovascular disease, cardiogenic shock, cardiac amyloidosis, and pulmonary hypertension.
- Heart failure
- Atrial fibrillation
- Acute myocardial infarction
- Stroke prevention
- Thromboembolic disease
Therapeutic emphasis includes cardiovascular risk reduction, anticoagulation-related care, and treatment strategies for inflammatory and cardiorenal overlap conditions.
Oncology and Hematologic Malignancies
Clinical trial activity spans breast cancer, non-small cell lung cancer, gastric cancer, colorectal cancer, melanoma, and prostate cancer, alongside extensive work in acute myeloid leukemia, acute lymphoblastic leukemia, multiple myeloma, and lymphoma. The research landscape also includes myeloproliferative neoplasms and other advanced solid and blood cancers.
- Breast cancer
- Lung cancer
- Leukemia
- Lymphoma
- Multiple myeloma
Therapeutic focus is centered on oncology innovation in targeted treatment, immunotherapy, and disease control across both solid tumors and hematologic cancers.
Autoimmune, Neurologic, and Respiratory Conditions
Research involvement includes myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, multiple sclerosis, juvenile psoriatic arthritis, and systemic sclerosis. Respiratory interests extend to idiopathic pulmonary fibrosis, severe eosinophilic asthma, and bronchiectasis.
- Myasthenia gravis
- Multiple sclerosis
- Autoimmune neuropathy
- Systemic sclerosis
- Fibrotic and eosinophilic lung disease
Therapeutic interests also include immune-mediated inflammation and progressive pulmonary disease requiring long-term disease-modifying treatment.
Metabolic, Renal, and Infectious Disease
Clinical research spans obesity, type 2 diabetes, chronic kidney disease, end-stage kidney disease, and membranous nephropathy. Infectious disease activity includes HIV, while additional interests cover hypertriglyceridemia, Graves’ disease, and antithrombin deficiency.
- Metabolic disease
- Chronic kidney disease
- HIV infection
- Hypertriglyceridemia
- Autoimmune renal disease
Therapeutic emphasis includes cardiometabolic risk, renal protection, and chronic infectious disease management within complex multisystem care.
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