Stefano C.
- Country
- Italy
- Department
- 3906: Gastroenterologia Pediatrica
Research Overview
- Phase 2a Randomized Open-Label Crossover Study of Oral NHS7108 in Adults with Exocrine Pancreatic Insufficiency
- Long-term Safety and Efficacy Evaluation of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients with Non-F508del CFTR Genotypes
- Evaluation of Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Cystic Fibrosis Patients with 3849+10 Kb C->T Mutation
Data & Insights
Has run more than one trial at 57 of 207 partner sites.
Specializations
Inflammatory Bowel Disease and Pediatric Gastroenterology
Clinical research activity centers on Crohn’s disease, ulcerative colitis, pouchitis, and related inflammatory bowel disease conditions in children, with interest in advanced biologic therapies and treatment optimization.
- Vedolizumab
- Risankizumab
- Infliximab durability
- Pediatric chronic pouchitis
The therapeutic focus includes disease control in pediatric gastrointestinal inflammation and maintenance of remission in complex intestinal disorders.
Cystic Fibrosis and Respiratory Disease
Research involvement extends to cystic fibrosis and other respiratory conditions, with attention to long-term disease management and inhaled therapies for airway disease.
- CFTR modulator therapy
- Inhaled treatment development
- Bronchiectasis
- Respiratory syncytial virus infection
Therapeutic interests also include respiratory support for chronic pulmonary complications and infection-related airway disease in vulnerable pediatric populations.
Hepatology, Metabolic Liver Disease, and Viral Hepatitis
Clinical trial activity covers metabolic dysfunction-associated steatohepatitis, non-alcoholic steatohepatitis, alcohol-related liver disease, hepatocellular carcinoma, and chronic hepatitis B.
- MASH and NASH
- Compensated cirrhosis
- Chronic hepatitis B
- Liver fibrosis
The therapeutic landscape includes liver injury, fibrotic progression, and antiviral strategies relevant to chronic hepatic disease.
Neuroimmunology, Neuromuscular Disease, and Pediatric Neurology
Investigator activity includes chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy, spinal muscular atrophy, Duchenne muscular dystrophy, and selected epilepsy syndromes in children and adolescents.
- Immune-mediated neuropathies
- Spinal muscular atrophy
- Duchenne muscular dystrophy
- Childhood absence epilepsy
Therapeutic interest is directed toward neuromuscular preservation, seizure control, and immune modulation in chronic neurologic disorders.
Pediatric Rheumatology, Renal Disease, and Ophthalmology
Additional research spans juvenile idiopathic arthritis, IgA nephropathy, hypertension, and ocular surface disease, reflecting involvement across autoimmune, renal, cardiovascular, and eye-related conditions.
- Juvenile idiopathic arthritis
- IgA nephropathy
- Corneal epithelial defects
- Dry eye disease
The therapeutic emphasis includes immune disease control, renal protection, and treatment of corneal and ocular surface pathology.
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