Staffan R.
- Country
- Sweden
- Department
- Clinical Pharmacology
Research Overview
- Evaluation of CPV-104 Pharmacokinetics, Safety, and Tolerability in Healthy Subjects and Patients with C3 Glomerulopathy
- Evaluation of TOL2 Safety, Tolerability, and Immune Response in Generalized Myasthenia Gravis Patients: A Phase I/IIa Randomized, Double-Blind, Placebo-Controlled Trial
- A First-in-Human, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study of Intrathecally Administered LTX-002 in Adult Participants with Amyotrophic Lateral Sclerosis
Data & Insights
Has run more than one trial at 1 of 24 partner sites.
Specializations
Oncology
Clinical research in solid tumours and haematologic malignancies spans a broad spectrum of cancers, including non-small cell lung cancer, breast cancer, colorectal cancer, urothelial carcinoma, prostate cancer, ovarian cancer, gastric cancer, and pancreatic cancer. The investigator is also involved in studies of lymphoma, acute myeloid leukaemia, chronic lymphocytic leukaemia, multiple myeloma, and myelodysplastic syndrome.
- Targeted cancer therapy
- Immuno-oncology
- Leukaemia and lymphoma
- Metastatic solid tumours
Research activity also extends to melanoma, glioblastoma, neuroendocrine tumours, and paediatric malignancies, reflecting involvement in advanced cancer care and therapeutic innovation across multiple tumour types.
Autoimmune and inflammatory diseases
The investigator is engaged in trials addressing rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, psoriatic arthritis, Crohn's disease, ulcerative colitis, and multiple sclerosis. Additional areas include vasculitis, myositis, atopic dermatitis, and hidradenitis suppurativa.
- Rheumatology
- Inflammatory bowel disease
- Neuroimmunology
- Immune-mediated skin disease
Clinical interests also include myasthenia gravis, primary Sjogren's syndrome, immune thrombocytopenia, and other autoimmune disorders requiring specialised immunomodulatory treatment.
Renal, transplant, and liver disorders
Research involvement covers chronic kidney disease, IgA nephropathy, focal segmental glomerulosclerosis, proteinuria, and end-stage kidney disease, alongside studies in kidney transplant rejection and renal transplantation. The investigator also works in liver disease and alcohol-related liver disease.
- Nephrology
- Transplant medicine
- Hepatology
- Immune-mediated organ injury
Additional interest includes primary sclerosing cholangitis, hepatitis B, hepatitis D, and alpha-1 antitrypsin deficiency, highlighting work across chronic organ-specific disease management.
Cardiometabolic and respiratory medicine
Clinical trial activity includes heart failure, atrial fibrillation, atherosclerotic cardiovascular disease, coronary artery disease, hypertension, and dyslipidemia. The investigator is also involved in asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and bronchiectasis.
- Cardiology
- Metabolic disease
- Respiratory disease
- Thromboembolic risk
Research also touches on obesity, type 2 diabetes, mixed dyslipidemia, and severe hypertriglyceridemia, supporting therapeutic work across linked cardiometabolic conditions.
Neurology and cognitive disorders
The investigator contributes to studies in Alzheimer's disease, frontotemporal dementia, Parkinson's disease, amyotrophic lateral sclerosis, mild cognitive impairment, and preclinical Alzheimer's disease. Additional areas include migraine, stroke, multiple sclerosis, and neuromyelitis optica spectrum disorder.
- Neurodegenerative disease
- Cognitive impairment
- Demyelinating disease
- Headache disorders
Research interests also include glioma, medulloblastoma, and other central nervous system pathology, with a focus on therapeutic development in complex neurological disease.
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