Solenne P.
- Country
- France
- Department
- Néphrologie
Research Overview
Data & Insights
Has run more than one trial at 21 of 34 partner sites.
Specializations
Chronic Kidney Disease & Cardiovascular Risk
The investigator explores the interplay between Chronic Kidney Disease and atherosclerotic disease, focusing on strategies that reduce cardiovascular events in patients with renal impairment.
- Risk stratification in CKD‑related hypertension
- Impact of lipid‑lowering therapies on renal outcomes
- Management of heart failure in advanced CKD
Research is conducted at Hospices Civils De Lyon and Centre Hospitalier Lyon Sud.
Acute Kidney Injury in Critical Care
Focused on the prevention and treatment of Acute Kidney Injury among intensive‑care patients, including those with sepsis and respiratory failure.
- Biomarker‑guided early detection
- Renal protective protocols during mechanical ventilation
- Outcomes of renal replacement therapy initiation timing
Collaborative work leverages the critical‑care units of the two Lyon sites.
Kidney Transplantation and Allograft Outcomes
Investigations address long‑term graft survival and complications such as rejection and infection in recipients of Kidney Transplantation.
- Immunosuppression minimization strategies
- Monitoring of donor‑derived cell‑free DNA
- Management of post‑transplant proteinuria
Both affiliated hospitals provide transplant cohorts for analysis.
Genetic and Metabolic Renal Disorders
The work includes rare inherited kidney diseases such as Autosomal Dominant Polycystic Kidney Disease and metabolic conditions leading to renal failure.
- Therapeutic modulation of cyst growth pathways
- Metabolic control in urea cycle disorders
- Evaluation of novel agents for hyperoxaluria
Patient registries at the Lyon centers support genotype‑phenotype correlation studies.
Autoimmune Renal Pathologies
Targeted research on immune‑mediated kidney injury, particularly Lupus Nephritis and other glomerulonephritides.
- Biologic therapies for refractory lupus nephritis
- Biomarker assessment of disease activity
- Kidney outcomes after systemic immunosuppression
The investigator collaborates with nephrology and rheumatology teams across both sites.
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