Simon G.
- Country
- Austria
- Department
- Department of Internal Medicine III
Research Overview
- Comparison of RO7771950 plus combination therapy versus tucatinib plus combination therapy in pretreated HER2-positive locally advanced or metastatic breast cancer
- Phase 3 Randomized Study of Gedatolisib Combination Therapy versus Standard Endocrine Therapy in HR‑Positive, HER2‑Negative Advanced Breast Cancer Post‑CDK4/6 Inhibitor
- Phase 3 Multicenter Randomized Open‑Label Trial of Efanesoctocog Alfa Intensified Replacement Therapy for Synovitis in Patients with Congenital Hemophilia A
Data & Insights
Has run more than one trial at 199 of 419 partner sites.
Specializations
Hormone Receptor-Positive Breast Cancer
The investigator specializes in studying advanced treatments for HR-positive/HER2-negative breast cancer, particularly focusing on therapeutic approaches for both early-stage and metastatic disease. Their research encompasses innovative combination therapies including endocrine treatment strategies.
- Locally recurrent inoperable breast cancer
- Metastatic disease management
- Adjuvant therapy optimization
The research extends to evaluating treatment outcomes in cases of isolated locoregional recurrence.
Triple-Negative Breast Cancer
Their expertise includes investigating novel therapeutic approaches for triple-negative breast cancer (TNBC) and hormone receptor-low/HER2-negative breast cancer. The research focuses on neoadjuvant and adjuvant treatment strategies.
- Immunotherapy combinations
- Targeted therapy approaches
- Treatment response assessment
The investigator evaluates innovative therapeutic combinations for improved patient outcomes.
Genetic and Molecular Subtypes
The investigator conducts research on specific molecular subtypes of breast cancer, including BRCA-mutated breast cancers and various HER2-negative subtypes. Their work involves evaluating targeted therapeutic approaches.
- BRCA mutation carriers
- HER2-negative disease variants
- Molecular targeted therapies
Research includes assessment of treatment efficacy in specific genetic subgroups.
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