Silvio Ken G.
- Country
- Italy
- Department
- Oncologia
Research Overview
- Phase 1b/2 Study of 5-Fluorouracil, Leucovorin, Irinotecan, Temozolomide, and Bevacizumab in MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer
- Phase II Study of Dostarlimab-Based Immunotherapy in Localized dMMR/MSI-H Esophagogastric Junction and Gastric Adenocarcinoma
- Efficacy and Safety of Zanidatamab with Cisplatin and Gemcitabine in Advanced HER2-Positive Biliary Tract Cancer: A Randomized Controlled Trial
Data & Insights
Has run more than one trial at 27 of 129 partner sites.
Specializations
Hematologic malignancies
The investigator is involved in clinical research on lymphoma and myeloid and plasma cell disorders, with emphasis on treatment strategies for follicular lymphoma, marginal zone lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, multiple myeloma, acute myeloid leukemia, and myelodysplastic syndromes.
- Relapsed and refractory lymphoma
- Multiple myeloma
- Acute myeloid leukemia
- Myelofibrosis and related disorders
Research activity also extends to chronic lymphocytic leukemia, Waldenström macroglobulinemia, peripheral T-cell lymphoma, and hairy cell leukemia, reflecting sustained interest in advanced hematologic oncology and novel immunotherapy-based approaches.
Solid tumors
Clinical trial involvement includes major solid tumor programs in breast cancer, lung cancer, gastroesophageal cancer, colorectal cancer, gastric cancer, ovarian cancer, esophageal carcinoma, and hepatocellular carcinoma.
- Breast and HER2-directed oncology
- Non-small cell lung cancer
- Gastrointestinal malignancies
- Gynecologic cancers
The portfolio also covers melanoma, bladder cancer, prostate cancer, and head and neck squamous cell carcinoma, indicating broad involvement in precision oncology and combination treatment development.
Autoimmune and inflammatory disease
The investigator participates in studies addressing immune-mediated conditions, including psoriatic arthritis, Sjögren’s syndrome, systemic lupus erythematosus, Crohn’s disease, ulcerative colitis, and idiopathic inflammatory myopathy.
- Rheumatologic disease
- Inflammatory bowel disease
- Systemic autoimmune disorders
- Musculoskeletal inflammatory syndromes
Additional interest is seen in diffuse cutaneous systemic sclerosis, axial spondyloarthritis, Graves’ disease, and myasthenia gravis, with a therapeutic focus on immune modulation and control of chronic inflammatory activity.
Cardiovascular, neurologic, and hematologic support therapies
Research involvement includes conditions such as heart failure, ischemic stroke, transient ischemic attack, recurrent pericarditis, venous thromboembolism, and hypertension, showing interest in cardiovascular risk reduction and organ-protective treatment strategies.
- Heart failure and vascular prevention
- Stroke prevention
- Thrombotic disorders
- Pericardial disease
The portfolio also includes hemophilia, graft-versus-host disease, and hematopoietic stem cell transplant-associated complications, highlighting engagement in supportive care and post-transplant therapeutic innovation.
Rare disease, infection, and ophthalmology
The investigator is also active in trials for mucopolysaccharidosis type II, partial lipodystrophy, and monkeypox virus disease, alongside studies in diabetic macular edema, neovascular age-related macular degeneration, and dry age-related macular degeneration.
- Rare metabolic disorders
- Viral infection
- Retinal disease
- Chronic inflammatory complications
This mix of programs includes invasive candidiasis, cytomegalovirus infection, and diabetic foot infections, reflecting involvement in both rare-disease therapeutics and clinically important infectious and ophthalmic conditions.
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