Silvana L.
- Country
- Italy
- Department
- U.O. Oncologia Medica
Research Overview
- Phase 2 Randomized Trial of Durvalumab Followed by Chemotherapy Versus Chemotherapy Followed by Durvalumab in Elderly Patients with Advanced NSCLC
- An Open-Label Randomized Trial Comparing Anakinra and Prednisone in Pediatric Colchicine-Resistant Recurrent Pericarditis
- Phase 3 Randomized Study of Intermittent vs. Continuous Panitumumab Plus FOLFIRI in Unresectable Left-Sided RAS/B-RAF Wild-Type Metastatic Colorectal Cancer
Data & Insights
Has run more than one trial at 90 of 352 partner sites.
Specializations
Haematologic Malignancies
Silvana Leo’s clinical research is strongly centered on acute myeloid leukemia, acute lymphoblastic leukemia, and other aggressive blood cancers, with activity spanning both adult and paediatric settings. Her trial portfolio also includes chronic lymphocytic leukemia, chronic myeloid leukemia, multiple myeloma, and lymphoma, reflecting a broad therapeutic focus in malignant haematology.
- Acute myeloid leukemia and molecularly defined subtypes
- Acute and chronic lymphoblastic leukaemias
- Chronic lymphocytic leukemia and small lymphocytic lymphoma
- Multiple myeloma and relapsed lymphoma
- Myelodysplastic syndromes and transplant-related care
Her work also extends to measurable residual disease-guided treatment strategies, allogeneic stem cell transplantation, and post-transplant management in high-risk haematologic disease.
Solid Tumours in Medical Oncology
Her oncology portfolio includes a wide range of solid tumours, with particular attention to breast cancer, non-small cell lung cancer, colorectal cancer, ovarian cancer, and prostate cancer. The research landscape also includes renal cell carcinoma, gastric cancer, cervical cancer, and pancreatic cancer.
- Breast cancer, including hormone receptor-positive disease
- Non-small cell lung cancer and biomarker-defined subsets
- Metastatic colorectal and pancreatic cancers
- Ovarian, cervical, and endometrial malignancies
- Renal cell carcinoma and prostate cancer
Her trial activity also covers targeted therapy, immunotherapy, and perioperative or adjuvant approaches in advanced and metastatic solid tumours.
Autoimmune and Inflammatory Diseases
Silvana Leo is involved in clinical research on juvenile idiopathic arthritis, including polyarticular and broader paediatric inflammatory phenotypes, as well as treatment strategies for recurrent pericarditis. These studies place emphasis on immune-mediated disease control and treatment adaptation in children and adolescents.
- Juvenile idiopathic arthritis
- Polyarticular-course juvenile idiopathic arthritis
- Recurrent pericarditis
- Anti-TNF treatment optimisation
- Paediatric immune-mediated disease management
Her research interest in this area also includes drug withdrawal, biosimilar use, and treat-to-target strategies in paediatric rheumatology.
Cardiovascular and Thrombotic Conditions
Her clinical trial activity includes cardiovascular and vascular medicine, with studies in ischemic stroke, transient ischemic attack, acute myocardial infarction, heart failure, and transthyretin amyloid cardiomyopathy. She is also involved in research on atherosclerotic cardiovascular disease and post-procedural cardiac complications.
- Stroke prevention and secondary vascular protection
- Acute coronary syndromes and myocardial injury
- Heart failure and low-cardiac output states
- Amyloid cardiomyopathy
- Perioperative cardiac support
This area also includes cardiorenal syndromes and interventions aimed at improving outcomes in patients with complex cardiovascular comorbidity.
Renal, Urologic, and Other Therapeutic Areas
Her research landscape further includes IgA nephropathy, end-stage kidney disease, and peritoneal ultrafiltration, alongside urologic oncology such as bladder carcinoma and prostate cancer. Additional activity covers selected rare and systemic conditions, including major depressive disorder, diabetes mellitus, and pneumococcal immunization.
- IgA nephropathy and kidney disease management
- Dialysis-related inflammatory and renal care
- Bladder and prostate malignancies
- Neuroendocrine neoplasms and mesothelial disease
- Selected metabolic, psychiatric, and preventive care topics
Her trial involvement in these domains reflects an interest in both chronic organ disease and oncology-related supportive care.
Related Investigators
Researchers in similar fields or departments
Want to know more about this investigator?
We can share extended profile information and contact details.
Is something out of date?
Tell us what needs correcting and we'll update this profile.