Silvan B.
- Country
- Germany
- Department
- Medizinische Klinik I
Research Overview
- Prospective, placebo-controlled clinical trial with Aconite Pain Oil in oncological patients undergoing chemotherapy to prevent chemotherapy-induced polyneuropathy (CIPN) grade II, to reduce symptoms typical of CIPN and to improve the quality of life of patients with CIPN
- Phase 3 Randomized Study of Tucatinib, Trastuzumab, and mFOLFOX6 vs. mFOLFOX6 with Cetuximab or Bevacizumab in HER2+ Metastatic Colorectal Cancer
- Evaluation of Adjuvant Therapy with Capecitabine in Stage II Colon and Rectal Cancer Patients with ctDNA Positivity Post-Resection
Data & Insights
Has run more than one trial at 123 of 371 partner sites.
Specializations
Breast Cancer and HER2-targeted therapy
The clinical research profile is centered on early, locally advanced, and metastatic breast cancer, with strong interest in HER2-positive, HR-positive/HER2-negative, and triple-negative breast cancer. The therapeutic landscape includes antibody-drug conjugates, endocrine therapy, CDK4/6 inhibition, and PI3K-pathway approaches.
- HER2-positive early and metastatic breast cancer
- HR-positive/HER2-negative breast cancer
- Triple-negative breast cancer
- Endocrine-based and targeted combinations
Research activity also extends to neoadjuvant and adjuvant treatment concepts in breast malignancy, including strategies aimed at reducing recurrence risk and improving disease control.
Gastrointestinal Oncology
The investigator is involved in clinical trials addressing colorectal cancer, colon cancer, rectal cancer, and gastroesophageal and gastric adenocarcinoma. The therapeutic focus includes perioperative, preoperative, and post-resection treatment strategies.
- Metastatic colorectal cancer
- Resectable colon and rectal cancer
- Esophagogastric junction cancer
- Advanced gastric adenocarcinoma
Additional interest is evident in treatment intensification and de-escalation approaches for gastrointestinal tumors, with attention to improving outcomes across locally advanced and metastatic disease settings.
Inflammatory Bowel Disease
Clinical trial involvement includes Crohn’s disease and ulcerative colitis, particularly in moderately to severely active disease. The therapeutic domain covers targeted immunomodulation, biologic therapy, and oral anti-inflammatory treatments.
- Crohn’s disease
- Ulcerative colitis
- Targeted therapy in immune-mediated disease
- Maintenance of clinical response
Research activity also includes studies focused on endoscopic and histologic improvement, reflecting a strong therapeutic interest in controlling intestinal inflammation and disease activity.
Thoracic Oncology and Solid Tumors
The investigator participates in research on non-small cell lung cancer, including advanced/metastatic and resectable disease, as well as broader studies in locally advanced or metastatic solid tumors. The therapeutic emphasis includes immunotherapy and combination systemic treatment.
- Non-small cell lung cancer
- Operable and advanced thoracic malignancies
- Metastatic solid tumors
- Immune-based cancer therapy
This area also connects with studies in urothelial carcinoma and other difficult-to-treat solid malignancies where systemic treatment innovation is a central theme.
Ovarian Cancer, Supportive Care, and Renal-Cardiovascular Disease
Additional research interests include platinum-resistant ovarian cancer, recurrent low-grade serous ovarian cancer, and supportive or comorbidity-focused areas such as chemotherapy-induced polyneuropathy, chronic kidney disease, and cardiovascular risk linked to hyperlipoproteinemia(a).
- Platinum-resistant ovarian cancer
- Recurrent low-grade serous ovarian cancer
- Chemotherapy-induced polyneuropathy
- Kidney and cardiovascular protection
Trial involvement also reflects interest in apheresis-related care and in therapeutic approaches that address complications and long-term disease burden alongside oncology treatment.
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