Sigrid V. B.
- Country
- The Netherlands
- Department
- Pulmonary Medicine
Research Overview
- Phase 2a Randomized, Double‑Blind, Placebo‑Controlled Study of Subcutaneous SAR445399 on Mucus Plug Score in Adults with Non‑Cystic Fibrosis Bronchiectasis
- VATS versus Intrapleural Alteplase/Dornase Alfa Enzymatic Therapy for Parapneumonic Pleural Infection (Empyema) in Patients Unresponsive to Antibiotics and Chest Tube Drainage
Data & Insights
Has run more than one trial at 2 of 21 partner sites.
Specializations
Oncology
Clinical investigations covering solid tumors and hematologic malignancies.
- Metastatic castration‑resistant prostate cancer
- Renal cell carcinoma
- Non‑small cell lung cancer
- Breast cancer
- Multiple myeloma
Research emphasizes targeted agents, immunotherapies, and combination regimens.
Cardiovascular & Metabolic Medicine
Studies address atherosclerotic cardiovascular disease and related metabolic risk factors.
- Atrial fibrillation
- High cardiovascular risk
- Statin intolerance
- Obesity
- Type II diabetes mellitus
Efforts focus on prevention of major adverse cardiovascular events and optimization of lipid‑lowering therapy.
Renal & Electrolyte Disorders
Investigations target kidney disease progression and dialysis‑related complications.
- Chronic kidney disease
- Immunoglobulin A nephropathy
- End‑stage kidney disease
- Urolithiasis
- Renal cell carcinoma
Therapeutic focus includes nephroprotective agents and management of proteinuria.
Respiratory & Pulmonary Medicine
Research spans chronic and acute lung conditions.
- Chronic obstructive pulmonary disease
- Severe asthma
- Bronchiolitis
- Lower respiratory tract infection
- Non‑cystic fibrosis bronchiectasis
Efforts aim to improve disease control, reduce exacerbations, and evaluate novel biologic therapies.
Autoimmune & Inflammatory Diseases
Focus on immune‑mediated disorders affecting multiple organ systems.
- Crohn’s disease
- Ulcerative colitis
- Rheumatoid arthritis
- Polymyalgia rheumatica
- Graves’ disease
Investigations explore biologic agents, disease remission endpoints, and quality‑of‑life outcomes.
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