Sigita H.
- Country
- Latvia
- Department
- Clinic of Oncology
Research Overview
- Phase 3 Evaluation of Pembrolizumab and Olaparib with Chemoradiation in Unresectable Stage III Non-Small Cell Lung Cancer
- Phase 3 Randomized Trial of Pembrolizumab Versus Placebo in Stage IB-IIIA NSCLC Post-Resection and Adjuvant Therapy
- Phase 3 Randomized, Double-Blind Study of Bemarituzumab with mFOLFOX6 in FGFR2b-Overexpressing Advanced Gastric or Gastroesophageal Junction Cancer
Data & Insights
Has run more than one trial at 42 of 193 partner sites.
Specializations
Gastroenterology and Inflammatory Bowel Disease
Clinical research activity includes therapies for Crohn’s disease and ulcerative colitis, with attention to disease control, maintenance treatment, and long-term safety in chronic intestinal inflammation.
- Crohn’s disease
- Ulcerative colitis
- Maintenance therapy
- Long-term safety
Interest extends to advanced immunomodulatory approaches used in immune-mediated gastrointestinal disease.
Cardiovascular and Thromboembolic Disease
Research involvement covers prevention and treatment strategies for atherosclerotic cardiovascular disease, atrial fibrillation, stroke, heart failure, and venous thromboembolism.
- Atherosclerotic cardiovascular disease
- Atrial fibrillation
- Ischemic stroke
- Heart failure
Therapeutic focus also includes lipid-lowering and antithrombotic innovation in high-risk vascular disease.
Oncology and Genitourinary Cancer
Clinical trial activity spans solid tumors, especially non-small cell lung cancer, urothelial cancer, and prostate cancer, with additional interest in multimodal cancer treatment.
- Non-small cell lung cancer
- Urothelial cancer
- Prostate cancer
- Muscle invasive bladder cancer
Research also includes immunotherapy, targeted oncology treatment, and adjuvant strategies in advanced malignancy.
Respiratory and Pulmonary Vascular Disease
Investigator involvement includes treatment studies in chronic obstructive pulmonary disease, asthma, bronchiectasis, pneumonia, and pulmonary arterial hypertension.
- Chronic obstructive pulmonary disease
- Asthma
- Bronchiectasis
- Pulmonary arterial hypertension
The therapeutic emphasis includes control of inflammatory airway disease and management of pulmonary vascular complications.
Neurology, Ophthalmology, and Autoimmune Disease
Research interests extend to multiple sclerosis, epilepsy, amyotrophic lateral sclerosis, diabetic macular edema, age-related macular degeneration, and systemic autoimmune disorders such as systemic lupus erythematosus and thyroid eye disease.
- Multiple sclerosis
- Epilepsy
- Diabetic macular edema
- Systemic lupus erythematosus
Additional therapeutic focus includes retinal disease, neuroinflammation, and immune-mediated neurologic conditions.
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