Shasine V.
- Country
- Bulgaria
- Department
- NA
Research Overview
- A Phase 2b Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Ritlecitinib in Adult Participants with Chronic Spontaneous Urticaria
- A Phase 3b Long-term Efficacy and Safety Extension Study of Barzolvolimab in Participants with Chronic Spontaneous Urticaria
- Phase IIIb Double-Blind Placebo-Controlled Trial of Betula Pollen Extract in Pediatric Birch Pollen-Induced Allergic Rhinoconjunctivitis with or without Asthma
Data & Insights
Has run more than one trial at 79 of 241 partner sites.
Specializations
Asthma and Type 2 inflammation
Clinical research activity includes moderate-to-severe asthma, severe asthma, and severe uncontrolled asthma, with interest in therapies aimed at improving symptom control, reducing exacerbations, and preserving lung function.
- Dupilumab
- Tezepelumab
- Verekitug
- PF-07275315
- GB-0895
The investigator’s work in this area also reflects involvement in biologic and targeted approaches for asthma with eosinophilic and inflammatory features.
Chronic Obstructive Pulmonary Disease
Research interests extend across COPD, including moderate-to-severe COPD, moderate to very severe COPD, and COPD with a history of exacerbations, focusing on symptom burden, exacerbation prevention, and respiratory outcomes.
- Triple inhaled therapy
- Itepekimab
- Tozorakimab
- AZD6793
- Depemokimab
Interest also includes long-term management strategies and novel anti-inflammatory approaches for former smokers with persistent obstructive lung disease.
Allergic and Urticarial Disorders
The investigator is involved in clinical studies of birch pollen-induced allergic rhinoconjunctivitis and chronic spontaneous urticaria, with emphasis on seasonal allergy control and treatment of persistent hives.
- Birch pollen immunotherapy
- Barzolvolimab
- Ritlecitinib
- Urticaria activity
This area highlights therapeutic interest in both allergen-directed and immune-modulating options for patients with refractory allergic and skin-related disease.
Hematologic Malignancies and Infection Prevention
Clinical trial involvement includes chronic lymphocytic leukemia, small lymphocytic lymphoma, multiple myeloma, and non-Hodgkin lymphoma, particularly in the setting of immune deficiency and infection risk.
- Hypogammaglobulinemia
- Major bacterial infections
- XEMBIFY
- Supportive care in hematologic cancer
These studies align with interest in reducing infectious complications in patients with B-cell malignancies and related immune suppression.
Cardiovascular, Renal, and Metabolic Disease
Additional research activity covers heart failure with impaired kidney function, chronic kidney disease with hypertension, and broader cardiovascular disease prevention, with attention to cardiorenal risk reduction.
- Heart failure events
- Albuminuria
- Lipoprotein(a)
- Coronary heart disease
The therapeutic scope includes interventions directed at cardiovascular protection, kidney function preservation, and prevention of major vascular events.
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