Serban T.
- Country
- Romania
- Department
- Psychiatry II Acutes
Research Overview
- Open-Label Long-Term Safety and Tolerability of ML-007C-MA (fesoterodine) in Adults with Hallucinations and Delusions of Alzheimer’s Disease Psychosis
- Efficacy and Safety Evaluation of Ulotaront (SEP-363856) in Acutely Psychotic Schizophrenia Patients: A Randomized, Double-Blind, Placebo-Controlled Study
- Efficacy and Safety Evaluation of ML-007C-MA in Treating Hallucinations and Delusions in Alzheimer's Disease Psychosis
Data & Insights
Has run more than one trial at 29 of 38 partner sites.
Specializations
Schizophrenia and acute psychosis
Clinical activity centers on schizophrenia, including acute psychotic episodes, persistent symptom control, and treatment-resistant presentations. The research profile also includes inpatient care for severe behavioral symptoms and adolescent-onset disease.
- Acute schizophrenia
- Behavioral and psychological symptoms of schizophrenia
- Inpatient schizophrenia care
- Adolescent schizophrenia
Areas of interest include symptom reduction, relapse prevention, and longer-term control of psychotic manifestations in both adult and younger populations.
Bipolar I disorder and manic syndromes
The investigator is involved in studies of bipolar I disorder, with emphasis on mania and mania with mixed features. The therapeutic focus extends to acute stabilization and maintenance-oriented management of manic symptoms.
- Bipolar I mania
- Mania with mixed features
- Acute manic episodes
- Adjunctive treatment for mania
Research activity also covers combination approaches for patients receiving mood-stabilizing treatment.
Alzheimer’s disease and neuropsychiatric symptoms
Another major area is Alzheimer’s disease with prominent neuropsychiatric symptoms, including agitation, hallucinations, and delusions. The work also addresses cognitive and global functional impairment associated with dementia.
- Agitation associated with Alzheimer’s disease
- Alzheimer’s disease psychosis
- Hallucinations and delusions
- Cognitive impairment in Alzheimer’s disease
This therapeutic domain reflects interest in managing both behavioral disturbance and cognitive decline in dementia care.
Major depressive disorder with residual symptoms
Clinical research also includes major depressive disorder with persistent symptom burden, especially anhedonia and insomnia. The focus is on adjunctive strategies for improving depressive symptoms and preventing relapse after initial response.
- Major depressive disorder with anhedonia
- Major depressive disorder with insomnia symptoms
- Relapse prevention in depression
- Adjunctive antidepressant therapy
These interests place emphasis on difficult-to-treat depressive features that affect recovery and long-term symptom control.
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