Ségolène M.
- Country
- France
- Department
- Anesthésie-Réanimation
Research Overview
- PROPHY-SEIN: Randomized Double‑Blind Non‑Inferiority Trial of Cefazolin Prophylaxis vs Placebo for Surgical Site Infection Prevention in Breast‑Conserving Surgery
- Comparative Efficacy of Cefoxitin Sodium Administration Regimens in Preventing Surgical Site Infections Post-Colorectal Surgery: A Multicenter RCT
Data & Insights
Has run more than one trial at 3 of 49 partner sites.
Specializations
Cardiovascular & Arrhythmia Management
The investigator concentrates on atrial fibrillation and related thromboembolic risk, as well as valve disease interventions.
- Management of atrial fibrillation with preserved ejection fraction
- Antithrombotic strategies after transcatheter aortic valve implantation
- Prevention of stroke in high‑risk cardiac patients
Emphasis is placed on integrating cardiology insights within intensive care settings.
Critical Care Organ Protection
Research includes renal protection during cardiopulmonary bypass and strategies to mitigate acute kidney injury after major cardiac surgery.
- Renal protection during cardiopulmonary bypass
- Prevention of acute kidney injury after cardiac surgery
- Hemodynamic optimization in the intensive care unit
The focus is on translating protective interventions into routine critical‑care practice.
Oncology – Targeted and Hormonal Therapies
The investigator is active in trials of androgen‑deprivation therapy combined with novel agents, as well as HER2‑targeted regimens for early breast cancer and radiotherapy‑based approaches for head‑and‑neck malignancies.
- Androgen‑deprivation therapy combined with novel agents
- HER2‑targeted regimens in early breast cancer
- Radiotherapy plus targeted drugs in head‑and‑neck carcinoma
Efforts aim to refine multimodal strategies that align with peri‑operative considerations.
Hepatology & Metabolic Liver Disease
Participation includes studies on non‑alcoholic steatohepatitis with fibrosis and on primary biliary cholangitis, evaluating therapeutic impact on liver histology.
- Non‑alcoholic steatohepatitis with fibrosis
- Primary biliary cholangitis management
- Therapeutic impact on liver histology
These projects integrate liver disease monitoring within critical‑care pathways.
Gastrointestinal Inflammatory Disorders
Focus areas cover advanced treatment strategies for Crohn’s disease and ulcerative colitis, employing biomarker‑guided adjustments and combination therapies.
- Crohn’s disease treatment escalation
- Ulcerative colitis combined modality therapy
- Biomarker‑guided therapeutic adjustments
The aim is to apply precision‑medicine concepts to severe intestinal inflammation.
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