Sebastian S. J.
- Country
- Germany
- Department
- Pedeatrics
Research Overview
- Evaluation of Midostaurin and Gemtuzumab Ozogamicin in Combination with Standard Induction Chemotherapy for Adult Acute Myeloid Leukemia
- Phase 3 Randomized Double-Blind Placebo-Controlled Study on Maralixibat Chloride Efficacy and Safety in Cholestatic Pruritus Treatment
- Long-Term Safety and Efficacy Evaluation of Maralixibat in Patients with Alagille Syndrome in the European Union
Data & Insights
Has run more than one trial at 7 of 45 partner sites.
Specializations
Paediatric Oncology and Haematologic Malignancies
Clinical research activity includes treatment strategies for childhood and adolescent cancers, with particular attention to acute leukaemias, lymphomas, neuroblastoma, medulloblastoma, and other solid tumours affecting younger patients.
- Acute lymphoblastic leukaemia
- Acute myeloid leukaemia
- Neuroblastoma
- Hodgkin lymphoma
- Peripheral T-cell lymphoma
Research interests also extend to post-transplant complications and treatment-related outcomes in paediatric haematology-oncology.
Breast Cancer and Hormone Receptor-Driven Therapy
The investigator is involved in trials centred on early, locally advanced, and metastatic breast cancer, especially HER2-negative and triple-negative disease, with a strong emphasis on endocrine-based and targeted treatment options.
- HR-positive, HER2-negative breast cancer
- Triple-negative breast cancer
- HER2-positive breast cancer
- Endocrine therapy
- CDK4/6 inhibition
Areas of interest include recurrence prevention, treatment resistance, and newer antibody-based and antibody-drug conjugate approaches.
Renal Disease, Kidney Transplantation, and Proteinuric Disorders
Research activity covers chronic kidney disease in children and adults, kidney transplantation, rejection-related conditions, and a broad spectrum of proteinuric glomerular diseases.
- Kidney transplant rejection
- Proteinuria
- Focal segmental glomerulosclerosis
- IgA nephropathy
- Alport syndrome
Additional interest is seen in paediatric renal transplantation and long-term management of immune-mediated renal injury.
Cardiovascular Medicine and Thromboembolic Disease
Clinical trial involvement includes atrial fibrillation, heart failure, myocardial infarction, stroke, and broader atherosclerotic cardiovascular disease, with attention to prevention and risk reduction.
- Atrial fibrillation
- Heart failure
- Acute ischemic stroke
- Acute coronary syndrome
- Venous thromboembolism
Therapeutic interests also include cardiometabolic risk and inflammatory contributors to vascular disease.
Autoimmune, Inflammatory, and Transplant-Related Disorders
The investigator is active in studies of immune-mediated disease, including atopic dermatitis, psoriasis, hidradenitis suppurativa, systemic lupus erythematosus, and myasthenia gravis, alongside transplant-associated immune complications.
- Atopic dermatitis
- Hidradenitis suppurativa
- Systemic lupus erythematosus
- Myasthenia gravis
- Chronic graft-versus-host disease
Research interests also include immune dysregulation in paediatric and post-transplant settings.
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