Sandica-Nicoleta B.
- Country
- Romania
- Department
- Sectia Clinica Gastroenterologie
Research Overview
- Effects of Plasma Exchange with Human Serum Albumin 5% (PE-A 5%) on Short-term Survival in Subjects with Acute-On-Chronic Liver Failure" (ACLF) at High Risk of Hospital Mortality
- Efficacy and Safety Evaluation of GS-1427 in Adults with Moderately to Severely Active Ulcerative Colitis: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study
- Phase 2 Adaptive Dose-Ranging Study of Eltrekibart and Mirikizumab in Adults with Moderately to Severely Active Ulcerative Colitis
Data & Insights
Has run more than one trial at 24 of 158 partner sites.
Specializations
Gastroenterology and Inflammatory Bowel Disease
Clinical research activity includes Crohn's disease, ulcerative colitis, and broader gastrointestinal inflammation, with interest in therapies aimed at controlling mucosal disease activity and maintaining remission.
- Moderately to severely active Crohn's disease
- Ulcerative colitis
- Clinical remission
- Endoscopic response
The therapeutic landscape also includes agents explored for long-term disease control in chronic intestinal immune-mediated disorders.
Hepatology and Metabolic Liver Disease
Research involvement extends to non-alcoholic steatohepatitis and advanced liver dysfunction, reflecting a focus on inflammatory and fibrotic liver conditions.
- Non-alcoholic steatohepatitis (NASH)
- Fibrosis
- Cirrhosis
- Acute-on-chronic liver failure
These studies align with therapeutic interest in interventions addressing liver injury, fibrotic progression, and severe hepatic decompensation.
Cardiovascular and Heart Failure Therapeutics
Clinical trial participation includes acute myocardial infarction, recurrent cardiovascular events, and heart failure with associated renal impairment or cardiomyopathy.
- Acute myocardial infarction
- Heart failure
- Non-ischemic cardiomyopathy
- Cardiovascular death
Additional interest includes therapies for thrombotic risk reduction and heart failure prevention in patients with complex cardiometabolic disease.
Neuropsychiatric and Alzheimer’s Disease Disorders
Research activity covers Alzheimer’s disease-related behavioral symptoms, bipolar-I disorder, and major depressive disorder, with attention to agitation, psychosis, mania, and mood stabilization.
- Agitation associated with Alzheimer’s disease
- Psychosis associated with Alzheimer’s disease
- Bipolar-I mania
- Major depressive disorder
The therapeutic scope also includes cognitive impairment and behavioral symptoms in neurodegenerative illness.
Autoimmune, Endocrine, and Infectious Disease Areas
Further involvement includes Sjögren’s syndrome, thyroid eye disease, congenital adrenal hyperplasia, Cushing syndrome, and viral lung infection, alongside urinary and dental bleeding-related conditions.
- Sjögren’s syndrome
- Thyroid eye disease
- Congenital adrenal hyperplasia
- Complicated urinary tract infection
These topics reflect therapeutic interest in immune-mediated disease, endocrine regulation, and treatment options for acute infectious complications.
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