Salvador G. C.
- Country
- Spain
- Department
- ESP020: Oncología
Research Overview
Data & Insights
Has run more than one trial at 0 of 53 partner sites.
Specializations
Hormone Receptor Positive Breast Cancer
The investigator concentrates on estrogen receptor‑positive, HER2‑negative breast malignancies, including advanced and metastatic disease settings.
- Endocrine resistance mechanisms
- CDK4/6 inhibitor combinations
- BRCA and homologous recombination repair alterations
Therapeutic strategies explore novel agents that restore hormone sensitivity and target DNA repair pathways.
KRAS G12C Mutant Solid Tumors
Focused on malignancies harboring the KRAS G12C mutation, spanning multiple organ sites such as lung, colorectal and pancreatic cancers.
- Targeted KRAS inhibition
- Combination regimens with immunotherapy
- Biomarker‑driven patient selection
Efforts aim to translate molecular profiling into effective targeted therapies for this oncogenic driver.
Advanced Gastrointestinal Malignancies
Extensive activity in tumors of the gastrointestinal tract, including colorectal, gastric, pancreatic and esophageal adenocarcinomas.
- First‑line and refractory treatment options
- DNA damage response inhibitors
- Anti‑angiogenic and checkpoint blockade combinations
Research emphasizes improving outcomes for patients with high‑risk or treatment‑resistant disease.
Hematologic Malignancies
Engagement in studies of myeloid and lymphoid neoplasms, such as acute myeloid leukemia, myelodysplastic syndrome and various non‑Hodgkin lymphomas.
- Targeted epigenetic therapies
- Novel antibody‑drug conjugates
- Immune‑based approaches for refractory disease
Therapeutic focus includes precision medicine strategies tailored to specific genetic lesions.
Rare and Refractory Solid Tumors
Investigations extend to uncommon and treatment‑refractory entities such as mesothelioma, cholangiocarcinoma, and glioblastoma.
- Biomarker‑guided enrollment
- Combination of targeted agents with radiotherapy
- Exploratory immunomodulatory regimens
These efforts address unmet clinical needs in cancers lacking standard therapeutic options.
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