Ruperto G. P.
- Country
- Spain
- Department
- Alergology
Research Overview
- A Phase 2b Dose-Ranging Study of Oral KT-621 in Adults with Uncontrolled Moderate to Severe Eosinophilic Asthma
- Non-Inferiority Trial of Depemokimab Versus Mepolizumab or Benralizumab in Severe Eosinophilic Asthma Patients
- Evaluation of Subcutaneous Immunotherapy with Der p 1/Der p 2/Der p 23 Allergens in Moderate/Severe Allergic Rhinitis/Rhinoconjunctivitis with/without Controlled Allergic Asthma
Data & Insights
Has run more than one trial at 22 of 166 partner sites.
Specializations
Alergology and respiratory allergy
Clinical research in allergic rhinitis, allergic rhinoconjunctivitis, and allergic asthma includes work on sensitization to Dermatophagoides species and Blomia tropicalis, with interest in persistent upper and lower airway disease.
- Moderate-to-severe allergic rhinitis
- Allergic rhinoconjunctivitis
- Eosinophilic asthma
- Severe asthma
Additional activity spans insomnia disorder with nocturia and immune-mediated eye and airway conditions linked to non-infectious uveitis.
Breast cancer and solid tumor oncology
Therapeutic interest is centered on breast neoplasms, including HER2-positive, HER2-negative, and hormone receptor-positive disease, with attention to advanced and recurrent settings and molecularly selected populations.
- Metastatic breast cancer
- Early breast cancer
- Triple negative breast cancer
- HER2-positive colorectal cancer
Work also extends to non-small cell lung cancer, small cell lung cancer, melanoma, and advanced solid tumors, reflecting a broad oncologic focus at Hospital Universitario De Canarias.
Hematologic malignancies and plasma cell disorders
Research activity includes multiple myeloma, smoldering multiple myeloma, relapsed or refractory multiple myeloma, and related plasma cell dyscrasias, together with chronic lymphocytic leukemia and diffuse large B-cell lymphoma.
- Newly diagnosed multiple myeloma
- Relapsed or refractory multiple myeloma
- Chronic lymphocytic leukemia
- Relapsed/refractory diffuse large B-cell lymphoma
Additional interest includes light chain amyloidosis and small lymphocytic lymphoma, covering both malignant and protein-deposition disorders.
Autoimmune and inflammatory disease
The investigator is involved in studies of systemic lupus erythematosus, lupus nephritis, Sjögren’s syndrome, psoriatic arthritis, and idiopathic inflammatory myopathies, with a strong therapeutic emphasis on immune dysregulation.
- Systemic lupus erythematosus
- Sjögren’s syndrome
- Psoriatic arthritis
- Idiopathic inflammatory myopathies
Related activity also covers Crohn’s disease, giant cell arteritis, and immune thrombocytopenia, indicating engagement with chronic inflammatory and systemic autoimmune conditions.
Rare diseases, metabolic disorders, and cardiovascular risk
Clinical interests include hypophosphatasia, Langerhans cell histiocytosis, primary hyperoxaluria, and metabolic syndrome, alongside transplantation-related metabolic complications and inherited disease.
- Hypophosphatasia
- Langerhans cell histiocytosis
- Primary hyperoxaluria
- Metabolic syndrome
Further involvement spans atherosclerotic cardiovascular disease, spontaneous coronary artery dissection, preeclampsia, and kidney transplantation, reflecting interest in complex systemic and vascular disease.
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