Rolf W.
- Country
- Germany
- Department
- Klinik und Poliklinik für Kardiologie
Research Overview
- Evaluation of Non-Vitamin K Oral Anticoagulants for Stroke Prevention in Patients with Perioperative Atrial Fibrillation Post-Noncardiac Surgery
- Efficacy of Cyclosporine A Versus Placebo in Reducing Myocardial Damage in Takotsubo Syndrome: A Phase II Randomized, Double-Blind, Placebo-Controlled Study
- Evaluation of Empagliflozin Continuation Versus Placebo in Patients with Acute Decompensated Heart Failure on SGLT2 Inhibitor Therapy
Data & Insights
Has run more than one trial at 28 of 370 partner sites.
Specializations
Cardiovascular disease and thromboembolic disorders
Clinical research activity includes atherosclerotic cardiovascular disease, heart failure, acute myocardial infarction, atrial fibrillation, hypertension, and pulmonary arterial hypertension, with interest in prevention of major cardiovascular and cerebrovascular events.
- Acute ischemic stroke and transient ischemic attack
- Heart failure and cardiometabolic risk
- Anticoagulation reversal and thrombosis prevention
Additional involvement extends to venous thromboembolism, resistant hypertension, and lipid-related risk in patients with elevated lipoprotein(a).
Hematologic malignancies and cellular therapy
Research spans acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, chronic lymphocytic leukemia, chronic myeloid leukemia, and multiple myeloma, alongside broader work in aggressive B-cell lymphoma and Hodgkin lymphoma.
- Myeloid neoplasms
- Lymphoid malignancies
- Stem cell transplantation
Therapeutic interests also include CAR T-cell therapy, allogeneic transplantation, and treatment strategies for relapsed or refractory disease.
Solid tumors and oncologic precision medicine
Investigational work covers breast cancer, gastroesophageal adenocarcinoma, gastric cancer, colorectal cancer, head and neck squamous cell carcinoma, melanoma, ovarian cancer, and biliary tract cancer.
- HER2-directed therapy
- Immune checkpoint blockade
- Targeted treatment in advanced solid tumors
There is also interest in biomarker-defined oncology, including PD-L1, HER2, and molecularly selected tumors across metastatic and locally advanced settings.
Liver disease and gastroenterology
Clinical trial involvement includes primary biliary cholangitis, primary sclerosing cholangitis, nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, cirrhosis, acute-on-chronic liver failure, and hepatocellular carcinoma.
- Cholestatic pruritus
- Fibrosis and cirrhosis
- Portal and hepatic complications
Research also extends to inflammatory bowel disease, gastroparesis, and post-gastrectomy care, reflecting a strong therapeutic focus on hepatobiliary and digestive disorders.
Autoimmune, renal, and neurologic disorders
Areas of interest include systemic lupus erythematosus, lupus nephritis, psoriatic arthritis, systemic sclerosis, rheumatoid arthritis, and granulomatosis with polyangiitis, together with atopic dermatitis and hidradenitis suppurativa.
- Glomerular disease and kidney function preservation
- Multiple sclerosis and neurodegenerative disease
- Chronic pain and neuropathy
Additional trial activity includes IgA nephropathy, autosomal dominant polycystic kidney disease, Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis.
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