Simona D. G.
- Country
- Italy
- Department
- Complex Operative Unit of Infectious disease I
Research Overview
- A Phase 3 Open-label Clinical Study of Doravirine/Islatravir (DOR/ISL [100 mg/0.25 mg]) Once Daily for the Treatment of HIV-1 Infection in Participants Who Previously Received DOR/ISL (100 mg/0.75 mg) QD in a Phase 3 Clinical Study
- A Phase 3, Randomized, Active-Controlled, Open-Label Clinical Study to Evaluate a Switch to Doravirine/Islatravir (DOR/ISL 100 mg/0.25 mg) Once-Daily in Participants With HIV-1 Who Are Virologically Suppressed on Antiretroviral Therapy
Data & Insights
Has run more than one trial at 16 of 55 partner sites.
Specializations
HIV Treatment Innovation
The investigator specializes in studying novel therapeutic approaches for Human Immunodeficiency Virus (HIV-1) treatment, with particular focus on evaluating simplified drug regimens and alternative treatment strategies.
- Two-drug versus three-drug regimens
- Early switching strategies in virologically suppressed patients
- Single-pill combination therapies
Their research encompasses evaluating the efficacy of new antiretroviral combinations and treatment optimization for HIV-positive individuals.
Treatment Optimization
Focus on investigating antiretroviral therapy modifications and treatment switches in patients who have achieved viral suppression, examining both immediate and delayed switching strategies.
- Fixed-dose combination tablets
- Once-daily oral regimens
- Weekly oral administration protocols
Their work includes assessment of novel drug combinations and dosing schedules to enhance treatment effectiveness.
Clinical Safety Assessment
Expertise in evaluating the safety and tolerability profiles of new antiretroviral medications and combination therapies for HIV-1 treatment.
- Long-term safety monitoring
- Comparative safety analyses
- Treatment-experienced patient outcomes
The investigator conducts comprehensive safety assessments of innovative HIV treatment approaches.
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