Risto J.
- Country
- Finland
- Department
- Abdominal surgery
Research Overview
Data & Insights
Has run more than one trial at 0 of 9 partner sites.
Specializations
Breast Cancer Therapeutics
Research concentrates on breast cancer subtypes, including hormone‑receptor positive, HER2‑negative, HER2‑positive and PIK3CA‑mutated disease.
- Selective estrogen receptor degraders for advanced disease
- CDK4/6 inhibitors combined with endocrine therapy
- Antibody‑drug conjugates targeting HER2
- Adjuvant endocrine strategies to reduce recurrence risk
Efforts aim to extend progression‑free survival and improve tolerability for patients undergoing curative or palliative treatment.
Lung Cancer Immunotherapy and Targeted Therapy
Focus is on non‑small cell lung cancer and small‑cell lung cancer, exploring novel checkpoint inhibitor combinations and targeted agents.
- PD‑L1 high expression strategies with anti‑TIGIT agents
- Combination chemotherapy with novel immunotherapies
- Maintenance therapy after induction with HER2‑targeted regimens
- Evaluation of radiotherapy plus immunotherapy in early‑stage disease
These studies seek to improve overall survival and disease control across disease stages.
Advanced Prostate Cancer Management
Investigations target metastatic castration‑resistant prostate cancer and high‑risk post‑prostatectomy recurrence.
- Androgen receptor degraders combined with standard hormonal therapy
- Apalutamide added to radiotherapy and LHRH agonists
- Novel hormonal agents evaluated for PSA response
- Combination strategies to delay metastatic progression
The goal is to extend metastasis‑free survival while maintaining quality of life.
Stroke, Atrial Fibrillation and Renal Risk Mitigation
Clinical work includes patients with acute ischemic stroke and those with atrial fibrillation and advanced chronic kidney disease.
- Anticoagulation with apixaban versus no anticoagulation
- Risk reduction for systemic embolism in dialysis‑dependent patients
- Safety profiling of novel antithrombotic agents
- Assessment of bleeding risk in stage 5 renal impairment
Research aims to balance thrombotic protection with bleeding safety in a high‑risk population.
Diagnostic Imaging for Acute Abdomen in Renal Impairment
Studies evaluate the superiority of intravenous contrast CT versus native CT for diagnosing acute abdomen in patients with reduced renal function.
- Diagnostic accuracy in identifying surgical emergencies
- Impact on postoperative morbidity and outcomes
- Renal safety of contrast administration in eGFR 15‑45 ml/min/1.73 m²
- Guideline development for imaging choice in compromised kidneys
Findings intend to optimize imaging protocols while preserving renal health.
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