Rikke E.
- Country
- Denmark
- Department
- Afd. for Kræftbehandling, KFE
Research Overview
- Evaluation of RO7276389 Monotherapy and Combination with Cobimetinib in BRAF-V600 Mutation-Positive Advanced Solid Tumors or Melanoma with CNS Metastases
- A Phase 1/Phase 2 Study to Evaluate the Safety and Tolerability of MK-1088 as Monotherapy and in Combination with Pembrolizumab in Participants with Advanced Solid Tumors
- A Phase 2 Study of Olaparib Monotherapy in Participants with Previously Treated, Homologous Recombination Repair Mutation (HRRm) or Homologous Recombination Deficiency (HRD) Positive Advanced Cancer
Data & Insights
Has run more than one trial at 22 of 107 partner sites.
Specializations
Gastrointestinal oncology
The investigator is active in clinical research on colorectal cancer, rectal cancer, pancreatic cancer, biliary tract cancer, hepatocellular carcinoma, and gastrointestinal stromal tumor, with additional involvement in anal squamous cell carcinoma and other advanced digestive malignancies.
- Advanced solid tumors
- Metastatic colorectal cancer
- Pancreatic ductal adenocarcinoma
- Ulcerative colitis
- Crohn’s disease
Therapeutic interests also include immune checkpoint inhibition, targeted therapy, and treatment strategies for inflammatory bowel disease.
Melanoma and skin cancer
Her oncology portfolio includes extensive work in melanoma, advanced melanoma, stage III melanoma, uveal melanoma, and basal cell carcinoma, covering both resected and metastatic disease settings.
- Malignant melanoma
- Cutaneous squamous cell carcinoma
- Non-melanoma skin cancer
- Stage IIB/C melanoma
- Perioperative immunotherapy
Research activity in this area is centered on adjuvant, neoadjuvant, and perioperative immunotherapy approaches for skin malignancies.
Genitourinary and gynecologic cancers
The investigator is involved in studies of renal cell carcinoma, urothelial cancer, bladder cancer, prostate cancer, endometrial cancer, ovarian cancer, cervical cancer, and vulvar cancer.
- Metastatic renal cell carcinoma
- Muscle-invasive bladder cancer
- Metastatic prostate cancer
- Endometrial carcinoma
- Gynecological malignancies
Therapeutic focus includes combination immunotherapy, hormone-directed treatment, and approaches for biomarker-defined solid tumors.
Thoracic and head and neck malignancies
Her clinical research includes non-small cell lung cancer, small cell lung carcinoma, mesothelioma, head and neck squamous cell carcinoma, and other advanced thoracic and upper aerodigestive tract cancers.
- Metastatic non-small cell lung cancer
- Extensive-stage small cell lung cancer
- Head and neck cancer
- Mesothelioma
- Advanced solid tumors
Areas of interest also include molecularly selected oncology and systemic treatment for difficult-to-treat metastatic disease.
Supportive care and non-oncologic therapeutics
Beyond cancer research, the investigator is engaged in studies of cardiovascular disease, heart failure, atrial fibrillation, chronic kidney disease, inflammatory bowel disease, migraine, prurigo nodularis, and Tourette’s disorder.
- Cardiovascular prevention
- Renal disease
- Neurological disorders
- Dermatologic disease
- Infectious complications
These interests reflect involvement in thrombosis prevention, renal protection, symptom control, and treatment of inflammatory and infectious conditions.
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