Rafael A. L.
- Country
- Spain
- Department
- 7005: Hematología
Research Overview
- Early treatment intensification in patients with high risk Mantle Cell Lymphoma using CAR-T-cell treatment after an abbreviated induction therapy with Rituximab and Ibrutinib and 6 months Ibrutinib maintenance (Arm A) as compared to standard of care induction and maintenance (Arm B)
- A phase 3 multicentre, randomized, prospective, open-label trial of Ibrutinib monotherapy versus fixed-duration Venetoclax plus Obinutuzumab versus fixed-duration Venetoclax plus Ibrutinib in patients with previously untreated chronic lymphocytic leukaemia (CLL) - CLL17
- Randomized European Trial of Autologous Transplantation with Rituximab, Ibrutinib, and Ara-C Induction in Generalized Mantle Cell Lymphoma
Data & Insights
Has run more than one trial at 125 of 333 partner sites.
Specializations
Lymphoma Research Focus
This investigator specializes in treating various forms of B-cell lymphomas, with particular emphasis on diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). Their research encompasses both newly diagnosed and relapsed/refractory cases.
- Advanced B-cell Non-Hodgkin Lymphomas
- Peripheral T-Cell Lymphoma
- Follicular Lymphoma
- Marginal Zone Lymphoma
The investigator evaluates novel therapeutic combinations including immunotherapy and targeted agents for lymphoma treatment.
Leukemia Studies
Their work extends to chronic lymphocytic leukemia (CLL) research, investigating innovative treatment approaches for both treatment-naïve and previously treated patients.
- First-line CLL Treatments
- Small Lymphocytic Lymphoma
- Novel Drug Combinations
The investigator explores fixed-duration therapeutic regimens and continuous treatment strategies in leukemia management.
Therapeutic Innovations
At the forefront of developing CAR-T cell therapies and investigating novel therapeutic agents, including:
- Targeted Molecular Therapies
- Immunotherapy Approaches
- Combination Treatment Strategies
- Monoclonal Antibody Therapies
Their research includes evaluation of experimental treatments against standard of care in hematologic malignancies.
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