Radu Bogdan M.
- Country
- Romania
- Department
- Gastroenterology
Research Overview
- N1T-MC-MALO: A Master Protocol for a Randomized, Controlled, Clinical Trial of Multiple Pharmacologic Agents in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Who Are at Increased Risk of Developing Major Adverse Liver Outcomes (SYNERGY-Outcomes); N1T-MC-TZ01 Tirzepatide in participants with high-risk MASLD; N1T-MC-RT01 Retatrutide in participants with high-risk MASLD
- A Phase 2b, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of 3 Active Dose Regimens of MORF-057 in Adults with Moderately to Severely Active Ulcerative Colitis (EMERALD-2)
- Phase 2 Study of LY4268989 Co-administered with Mirikizumab in Adults with Moderately to Severely Active Ulcerative Colitis
Data & Insights
Has run more than one trial at 432 of 684 partner sites.
Specializations
Inflammatory Bowel Disease
The clinical research profile includes a strong focus on Crohn’s disease and ulcerative colitis, with interest in advanced therapies for persistent intestinal inflammation, mucosal healing, and long-term disease control.
- Moderately to severely active Crohn’s disease
- Moderately to severely active ulcerative colitis
- Endoscopic response and clinical remission
- Maintenance treatment in chronic relapsing bowel disease
Research activity also extends to gastroesophageal reflux disease-related erosive esophagitis and broader gastrointestinal inflammatory conditions.
Autoimmune and Immune-Mediated Disease
Another major area of interest is autoimmune disease, particularly disorders affecting the skin, joints, and connective tissue, including psoriatic arthritis, systemic lupus erythematosus, cutaneous lupus erythematosus, and systemic sclerosis.
- Active psoriatic arthritis
- Systemic lupus erythematosus
- Cutaneous lupus erythematosus
- Systemic sclerosis and Sjögren’s disease
The investigator is also involved in studies addressing idiopathic inflammatory myopathies, including dermatomyositis, and other immune-mediated inflammatory syndromes.
Dermatologic Inflammation and Skin Disorders
Clinical trial involvement shows a sustained interest in atopic dermatitis, hidradenitis suppurativa, and plaque psoriasis, reflecting a therapeutic emphasis on chronic inflammatory skin disease and symptom burden.
- Moderate to severe atopic dermatitis
- Moderate-to-severe hidradenitis suppurativa
- Moderate to severe plaque psoriasis
- Skin manifestations of lupus
Research activity also includes conditions linked to pruritus, barrier dysfunction, and inflammatory skin control across adult and pediatric populations.
Hematologic Malignancies and Bone Marrow Disorders
The investigator is engaged in studies of hematologic cancers and marrow failure syndromes, including acute myeloid leukemia, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, and myelofibrosis.
- Acute myeloid leukemia and relapsed/refractory disease
- Follicular and marginal zone lymphoma
- Primary and secondary myelofibrosis
- Multiple myeloma and non-Hodgkin lymphoma
Additional interest includes supportive care for infection risk and immune deficiency in patients with lymphoproliferative disorders.
Chronic Infection, Liver Disease, and Cardiometabolic Conditions
Research involvement also covers chronic hepatitis B, chronic hepatitis C virus infection, metabolic dysfunction-associated steatotic liver disease, and acute-on-chronic liver failure, alongside selected cardiometabolic and infectious complications.
- Chronic hepatitis B and hepatitis C infection
- Metabolic dysfunction-associated steatotic liver disease
- Acute-on-chronic liver failure
- Chronic heart failure and atrial fibrillation
Additional trial activity includes resistant hypertension, complicated urinary tract infection, and prevention of thromboembolic events in cardiovascular disease.
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