Porin M.
- Country
- Croatia
- Department
- Affective Disorders
Research Overview
- Efficacy and Safety Evaluation of 9-(4-Cyclohexyloxyphenyl)-7-Methyl-3,4-Dihydropyrazino[2,1-c][1,2,4]Thiadiazine 2,2-Dioxide as Adjunctive Therapy in Major Depressive Disorder
- Evaluation of Long-Term Safety and Tolerability of NBI-1065845 as Adjunctive Therapy in Adults with Major Depressive Disorder
Data & Insights
Has run more than one trial at 15 of 79 partner sites.
Specializations
Alzheimer’s disease and related neuropsychiatric symptoms
Porin Makaric is involved in clinical research on Alzheimer’s disease with a strong focus on behavioral and psychiatric complications, including agitation, psychosis, and cognitive impairment linked to dementia.
- Agitation in dementia
- Psychosis associated with Alzheimer’s disease
- Mild to moderate Alzheimer’s disease
His trial portfolio reflects interest in symptom control for dementia-related distress and functional decline in a psychiatric clinical setting.
Bipolar I disorder and mania
His research includes treatment-focused studies in bipolar I disorder, with attention to acute mania and mania with mixed features as key therapeutic targets.
- Bipolar I mania
- Mania with mixed features
- Acute manic episodes
This area highlights clinical interest in stabilizing severe mood elevation and related behavioral symptoms.
Schizophrenia and persistent psychotic symptoms
Porin Makaric is active in studies addressing schizophrenia and associated psychosis, including treatment-refractory symptoms and ongoing safety evaluation in patients with chronic psychotic illness.
- Schizophrenia
- Psychosis
- Cognitive impairment in schizophrenia
His work also extends to long-term tolerability questions relevant to sustained management of psychotic disorders.
Major depressive disorder
His clinical research includes adjunctive strategies for major depressive disorder, with emphasis on improving depressive symptoms in adults who need additional therapeutic support.
- Major depressive disorder
- Adjunctive depression treatment
- Symptom reduction in depression
This area reflects involvement in treatment approaches for persistent mood symptoms within affective disorders.
Tardive dyskinesia and movement-related adverse effects
His portfolio also includes research on tardive dyskinesia, focusing on involuntary movement disorders seen in patients with chronic psychiatric illness and prior antipsychotic exposure.
- Tardive dyskinesia
- Neuroleptic-induced movement disorders
- Schizophrenia-related motor symptoms
This domain adds a movement-disorder dimension to his psychiatric research profile.
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